Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1234578..1235116 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JWZ98_RS05870 Protein ID WP_205453614.1
Coordinates 1234832..1235116 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JWZ98_RS05865 Protein ID WP_205453613.1
Coordinates 1234578..1234835 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS05835 1231096..1231770 + 675 WP_205453607.1 hypothetical protein -
JWZ98_RS05840 1231767..1232030 + 264 WP_205453608.1 hypothetical protein -
JWZ98_RS05845 1232005..1232712 + 708 WP_205453609.1 DNA-binding domain-containing protein -
JWZ98_RS05850 1232840..1233151 - 312 WP_205453610.1 integration host factor subunit beta -
JWZ98_RS05855 1233662..1234282 + 621 WP_205453611.1 recombinase family protein -
JWZ98_RS05860 1234286..1234528 + 243 WP_205453612.1 WGR domain-containing protein -
JWZ98_RS05865 1234578..1234835 + 258 WP_205453613.1 ribbon-helix-helix protein, CopG family Antitoxin
JWZ98_RS05870 1234832..1235116 + 285 WP_205453614.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JWZ98_RS05875 1235433..1236461 + 1029 WP_205453615.1 DUF2806 domain-containing protein -
JWZ98_RS05880 1236728..1237903 + 1176 WP_205450356.1 integrase -
JWZ98_RS05885 1237941..1238888 + 948 WP_205453616.1 IS481 family transposase -
JWZ98_RS05890 1238920..1239651 - 732 WP_205453617.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1233662..1238888 5226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10911.60 Da        Isoelectric Point: 8.5282

>T194177 WP_205453614.1 NZ_CP070494:1234832-1235116 [Methylomonas sp. EFPC1]
VKLVWTEPARQDLREIFTYIAEENPNAARRLLAEIKERAILLQDNPQIGRAGRVDGTRELVITGTQYILPYRLKELQIQI
LAVFHGARLWPDNF

Download         Length: 285 bp

>T194177 NZ_CP093376:213113-213400 [Cronobacter sakazakii]
ATGAGCTATAAACTGGTCTTTGACCCACGTGCGCTGAAGGAGTGGCACAAACTGGGCGAGACCGTTAAAGCGCAATTCAA
AAAGAAGCTGGCGCACGTGCTGGCGGCTCCCAGGGTGAAATCCGCCCGGTTAAGTGGCCTGCCGGACTGCTACAAAATTA
AATTAAGAACGAGCGGTTACCGGCTGGTGTATCAGGTGCGCGATGACGCTGTCTGTGTGCTGGTCATCGCGATCGGCAAA
CGCGAAAACTTGACCGTATACCAGGGTGCCGGGCACCGTCTGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9684.90 Da        Isoelectric Point: 4.8616

>AT194177 WP_205453613.1 NZ_CP070494:1234578-1234835 [Methylomonas sp. EFPC1]
MATEAFTVRAESDIVHQLDFIAGALDRSRNYLVNQALREYLKTHAWQVEKITQGIAAADRGELVDHDDVMREMEELIEQK
AKGRA

Download         Length: 258 bp

>AT194177 NZ_CP093376:212881-213123 [Cronobacter sakazakii]
ATGGCCACAATCAACGTAAGGCTTGATGACAAGCTTAAAAATGAGGCTTATGCGGTGCTGGAAAAACTGGGTATCACACC
TACCGAAGCGGTGCGTCTGCTGTTTCAGTATGTGGCACAAAATGGCCGTATGCCGGTCAAAACGCTAACCGTCAGCGACA
GCGAAGAGGCGCTGCTGCGTACCGTGCGTGAGCGACTGGCGGACCCGCGGCCGGGCATCAGGGTTGATCTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References