Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 11932..12418 Replicon plasmid unnamed2
Accession NZ_CP070493
Organism Methylococcus sp. EFPC2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JWZ97_RS19835 Protein ID WP_205434873.1
Coordinates 12155..12418 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JWZ97_RS19830 Protein ID WP_205434872.1
Coordinates 11932..12168 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ97_RS19805 8523..10655 - 2133 WP_205434869.1 DEAD/DEAH box helicase family protein -
JWZ97_RS19810 10652..10963 - 312 WP_205434875.1 WGR domain-containing protein -
JWZ97_RS19815 11121..11309 + 189 WP_205434870.1 hypothetical protein -
JWZ97_RS19820 11367..11581 - 215 Protein_14 hypothetical protein -
JWZ97_RS19825 11578..11859 - 282 WP_205434871.1 DUF1778 domain-containing protein -
JWZ97_RS19830 11932..12168 - 237 WP_205434872.1 CopG family transcriptional regulator Antitoxin
JWZ97_RS19835 12155..12418 - 264 WP_205434873.1 BrnT family toxin Toxin
JWZ97_RS19840 12536..12991 - 456 WP_205434876.1 hypothetical protein -
JWZ97_RS19845 13015..15009 - 1995 WP_205434849.1 relaxase/mobilization nuclease domain-containing protein -
JWZ97_RS19850 15170..15550 - 381 WP_205434850.1 conjugal transfer transcriptional regulator TraJ -
JWZ97_RS19855 15935..16351 + 417 WP_205434851.1 hypothetical protein -
JWZ97_RS19860 16378..17013 - 636 WP_205434852.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25893 25893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin

CopG antitoxin

(5-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10185.51 Da        Isoelectric Point: 6.2258

>T194175 WP_205434873.1 NZ_CP070493:c12418-12155 [Methylococcus sp. EFPC2]
MSFEYDQDKNIANLAKHGIDFEQAQALWEDPELLEIPAKTTDEPRFLVIGRIGSKHWSAVVTYRNSHIRLISVRRSRKEE
VQLYESI

Download         Length: 264 bp

>T194175 NZ_CP093376:c19529-19224 [Cronobacter sakazakii]
ATGAAGCATATTTTTCAAACTGAAGTATTCCGCCGCTGGCAAGCCAGTCTGAAAGACCAGCGGGTAAAAACGATGATTGC
CGCGCGGCTTTTTCGGCTGGCTAATGGTTTGCCTGGTGATGTTAAGCCCGTCGGCGCAGGCATCAGTGAACTGCGTATTC
ACTACGGCGCGGGATACCGGATTTATTTCAAACAACACGGCGAGGTGATTGTCATTTTGCTTTGTGGTGGTGATAAGCAC
ACGCAGGATAAAGACATTCTTCTTGCGAAAATGCTGGCTGACCTGCCAGAGAACCAGTGGAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8947.17 Da        Isoelectric Point: 6.6424

>AT194175 WP_205434872.1 NZ_CP070493:c12168-11932 [Methylococcus sp. EFPC2]
MKASEFDQQFDDGEDITALLDLSKAHRPGLEAKRINVDFPSWMVHSLDKEAHRLGVTRQSLIKLWLADKLDHLRPHTG

Download         Length: 237 bp

>AT194175 NZ_CP093376:c19219-18944 [Cronobacter sakazakii]
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References