194173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/PRK10514-DUF1778
Location 2077..2973 Replicon plasmid unnamed2
Accession NZ_CP070493
Organism Methylococcus sp. EFPC2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JWZ97_RS19765 Protein ID WP_205434861.1
Coordinates 2077..2586 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JWZ97_RS19770 Protein ID WP_205434862.1
Coordinates 2674..2973 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ97_RS19750 6..752 + 747 WP_205434859.1 TIGR02391 family protein -
JWZ97_RS19755 791..1705 + 915 WP_205434874.1 tyrosine-type recombinase/integrase -
JWZ97_RS19760 1791..2066 + 276 WP_205434860.1 DUF1778 domain-containing protein -
JWZ97_RS19765 2077..2586 + 510 WP_205434861.1 GNAT family N-acetyltransferase Toxin
JWZ97_RS19770 2674..2973 + 300 WP_205434862.1 DUF1778 domain-containing protein Antitoxin
JWZ97_RS19775 2974..3462 + 489 WP_205434863.1 GNAT family N-acetyltransferase -
JWZ97_RS19780 3466..3861 + 396 WP_205434864.1 hypothetical protein -
JWZ97_RS19785 3957..4115 + 159 WP_205434865.1 hypothetical protein -
JWZ97_RS19790 4251..5585 - 1335 WP_205434866.1 hypothetical protein -
JWZ97_RS19795 5707..6882 - 1176 WP_205434867.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25893 25893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-146)

Antitoxin

Vibrio phage ICP1, Orf50

(13-98)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18441.43 Da        Isoelectric Point: 8.9085

>T194173 WP_205434861.1 NZ_CP070493:2077-2586 [Methylococcus sp. EFPC2]
MEETPKPSIAKLSIEHDPSTFDCGHKALNTFIRLHALPGQQANISQTYVAVVGQTIVGFHTLVVGDVAYDDAPERLAKGL
PRHPVPILLLARLAVDRTWQGKGLGAALVTDAMRRTLQVADIAGVRALLVHAKNEAAKSFYTHLGFEPFLGEPLILYRLL
KDLRVMSNG

Download         Length: 510 bp

>T194173 NZ_CP093375:c48044-46725 [Cronobacter sakazakii]
ATGCGCCGCACGTCGCGTTTAGCGCTCTGGATGAACGGCCTGCCGGTCGGTTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCATACCGTGGCGCGCAGGTGCGCGATTACTTCGACAACCTGCTGCCGGACAGCGAAAACATCCGGCGGCGGCTGGCG
ATGCGCTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGACGCGACTGTGTGGGCGCCATCCAGCT
GTTGCCCGCCGGTGAAGCACCGGAAGGGCTTTTTACCATCCGCGCCCGTCCACTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCGTTCCCCGGCCAGCATGGCGGCGAAGAGGAGCTGCGCCTCTCCATTGCGGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGAAGGCCAGTGGTGCCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAATATGCAGGCGGATATGCGCACCTCCATTGAAAACGAATGGCTCTGTGCGCAACTGCTGGCGG
CCTGGGATATTCCGGTCGCGCACACGCAGATGGCGCAGTTCGAAGAGCAAAAAGTGCTGATTGTCGAACGCTTCGACCGG
CGTCTTTCGGCCGATGGCCAGTGGTGGCTGCGTCTGCCGCAGGAGGATATGTGCCAGGCGCTGGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGGGATATCATGACCATCCTGAGCCGTTCAGAAAACGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATTTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATTGCG
CATCTGCCCGGCAACCGCTACCACCTGACGCCGCTTTACGACGTGCTCTCCGCCTGGCCGGTCATCGGGCCGGGTAATAA
CCAGATTGCGTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCGGCGGCAGTAACTATTACCACCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCTGCGGTGTTCGCGCGCGTGGCCGACGCGCTCCCGGTGGATTTCCCCGCCTCTCTGGCCGACGTTATTTTTAA
CGGCATGCGCCAGCAGTGCGCGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11468.09 Da        Isoelectric Point: 7.9908

>AT194173 WP_205434862.1 NZ_CP070493:2674-2973 [Methylococcus sp. EFPC2]
MRPTETTESSSQPRDININIRAKRRQRDLIDRAAELLGKTRSDFMLETACREAEDVLLDQRIFTLEPETFRKFQALLDAP
PSENAKLRKLLATKAPWEP

Download         Length: 300 bp

>AT194173 NZ_CP093375:c48328-48047 [Cronobacter sakazakii]
ATGAACACCCGGTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAAACAGGGGCTGAC
CCAGAAAGAAGTTTCGGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAGACGGCCAGCA
TTGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCGGAGCCTGACGCG
CCTGCGTGTGACGATTCGCCTGCCCACCGCGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References