Detailed information of TA system TA194171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 30682..31184
• Replicon: plasmid unnamed1
• Accession: NZ_CP070492
• Organism: Methylococcus sp. EFPC2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JWZ97_RS19380
• Protein ID: WP_205434825.1
• Coordinates: 30930..31184 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JWZ97_RS19375
• Protein ID: WP_205434824.1
• Coordinates: 30682..30933 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWZ97_RS19350	28069..28602	+	534	WP_205434819.1	flavodoxin	-
JWZ97_RS19355	28702..28944	-	243	WP_205434820.1	DUF2442 domain-containing protein	-
JWZ97_RS19360	28948..29202	-	255	WP_205434821.1	DUF4160 domain-containing protein	-
JWZ97_RS19365	29606..29929	-	324	WP_205434822.1	hypothetical protein	-
JWZ97_RS19370	30113..30529	-	417	WP_205434823.1	hypothetical protein	-
JWZ97_RS19375	30682..30933	+	252	WP_205434824.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JWZ97_RS19380	30930..31184	+	255	WP_205434825.1	Txe/YoeB family addiction module toxin	Toxin
JWZ97_RS19385	31583..33178	+	1596	WP_205434826.1	FAD-dependent oxidoreductase	-
JWZ97_RS19390	33208..34323	+	1116	WP_205434827.1	ATP-binding cassette domain-containing protein	-
JWZ97_RS19395	34363..34674	+	312	WP_205434828.1	hypothetical protein	-
JWZ97_RS19400	34967..35710	+	744	WP_205434829.1	YkgJ family cysteine cluster protein	-
JWZ97_RS19405	35776..36045	-	270	WP_205434830.1	BolA/IbaG family iron-sulfur metabolism protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..89615	89615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10241.74 Da
• Isoelectric Point: 9.3515

>T194171 WP_205434825.1 NZ_CP070492:30930-31184 [Methylococcus sp. EFPC2]
VRLIFAEAAWEDYLYWQQHDRRMVERINKLIRETQREPYAGIGKPEPLKHALAGFWSRRITDEHRMVYRVEGDALLLAQL
RYHY

Nucleotide

• Length: 255 bp

>T194171 NZ_CP093374:c223791-223639 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9063.26 Da
• Isoelectric Point: 4.7513

>AT194171 WP_205434824.1 NZ_CP070492:30682-30933 [Methylococcus sp. EFPC2]
MDAITYSAARANLANTMDRVCEDHEPLIITRNGQRSVVMLSLEDYQALEETAYLLRSPANAKRLLAAAAQLAAGKGTERE
LAE

Nucleotide

• Length: 252 bp

>AT194171 NZ_CP093374:223843-223903 [Salmonella enterica subsp. enterica serovar Infantis]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT