Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4163194..4163747 Replicon chromosome
Accession NZ_CP070491
Organism Methylococcus sp. EFPC2

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JWZ97_RS17875 Protein ID WP_205431948.1
Coordinates 4163430..4163747 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JWZ97_RS17870 Protein ID WP_205431947.1
Coordinates 4163194..4163430 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ97_RS17845 4159157..4159525 + 369 WP_205431932.1 ArsC family reductase -
JWZ97_RS17850 4159522..4160649 + 1128 WP_205431941.1 succinyl-diaminopimelate desuccinylase -
JWZ97_RS17855 4160777..4161262 + 486 WP_205431943.1 redoxin domain-containing protein -
JWZ97_RS17860 4161274..4162335 + 1062 WP_205434714.1 zinc-binding dehydrogenase -
JWZ97_RS17865 4162340..4163101 + 762 WP_205431945.1 SEL1-like repeat protein -
JWZ97_RS17870 4163194..4163430 + 237 WP_205431947.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JWZ97_RS17875 4163430..4163747 + 318 WP_205431948.1 CcdB family protein Toxin
JWZ97_RS17880 4163797..4165149 + 1353 WP_205431949.1 beta-glucosidase -
JWZ97_RS17885 4165176..4166339 + 1164 WP_205431950.1 acetylornithine deacetylase -
JWZ97_RS17890 4166700..4166798 + 99 WP_205434715.1 PTPA-CTERM sorting domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11310.29 Da        Isoelectric Point: 6.7185

>T194170 WP_205431948.1 NZ_CP070491:4163430-4163747 [Methylococcus sp. EFPC2]
MAQFDVYPNPHAGQKHIIPFLLDVQSDLLGALNTTVVVPFYDPAAVSISPIRGLMPVFEVQGQSYVMVSTELAGVPRKRL
PPGVANLGVHRSIIMAALDIILTGF

Download         Length: 318 bp

>T194170 NZ_CP093374:49819-50124 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9017.15 Da        Isoelectric Point: 7.2048

>AT194170 WP_205431947.1 NZ_CP070491:4163194-4163430 [Methylococcus sp. EFPC2]
MAAHPTTKKSANLSVRSDLLAEAKALNINLSQAFETHLSELVKIKKRERWLEENREAIEAYNRRVEEDGVFSDAWRSF

Download         Length: 237 bp

>AT194170 NZ_CP093374:49599-49817 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References