Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2540790..2541901 Replicon chromosome
Accession NZ_CP070491
Organism Methylococcus sp. EFPC2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JWZ97_RS10710 Protein ID WP_205428778.1
Coordinates 2540790..2541545 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JWZ97_RS10715 Protein ID WP_205428779.1
Coordinates 2541542..2541901 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ97_RS10690 2535800..2536189 + 390 WP_205428771.1 preQ(1) synthase -
JWZ97_RS10695 2536255..2540049 - 3795 WP_205428772.1 hypothetical protein -
JWZ97_RS10700 2540167..2540451 - 285 WP_205428774.1 type II toxin-antitoxin system RelE/ParE family toxin -
JWZ97_RS10705 2540441..2540680 - 240 WP_205428776.1 ribbon-helix-helix protein, CopG family -
JWZ97_RS10710 2540790..2541545 - 756 WP_205428778.1 RES domain-containing protein Toxin
JWZ97_RS10715 2541542..2541901 - 360 WP_205428779.1 DUF2384 domain-containing protein Antitoxin
JWZ97_RS10720 2542020..2542655 - 636 WP_205428781.1 MOSC domain-containing protein -
JWZ97_RS10725 2542686..2543267 - 582 WP_205428783.1 ribonuclease HII -
JWZ97_RS10730 2543271..2544041 - 771 WP_205428785.1 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase -
JWZ97_RS10735 2544047..2544478 - 432 WP_205428787.1 3-hydroxyacyl-ACP dehydratase FabZ -
JWZ97_RS10740 2544531..2545049 - 519 WP_205428789.1 OmpH family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(65-213)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-64)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 27494.22 Da        Isoelectric Point: 6.4952

>T194169 WP_205428778.1 NZ_CP070491:c2541545-2540790 [Methylococcus sp. EFPC2]
MSAGIWSACAGADSCVPLEGSLFRIVESQVQIATHRLVSTLEEQALLEELLETAKPPLAAGTASLHYLLATPFRYPPLRH
GSRFGRRHEPSLFYGSLAVDTVLAEAAYYRLVFWQGMEVAPKAPLATQHTMFEARYACRRGVRLHQPPFDAWRAELVHPA
SYVATQALGSEMRAAGVEAFEFTSARHPEGGVNVALFTPSALASRRPESTQNWQAETIGDHVSFYSPEQAAFHGFELSIF
LVDGKLPIPAG

Download         Length: 756 bp

>T194169 NZ_CP093374:c48749-48333 [Salmonella enterica subsp. enterica serovar Infantis]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12946.96 Da        Isoelectric Point: 10.6110

>AT194169 WP_205428779.1 NZ_CP070491:c2541901-2541542 [Methylococcus sp. EFPC2]
MNTVLKIKAQSSQVLATAFLRAGKELGLSQAALEEIIDRNRSSISRNGIDPQTKSGELALLFIRAYRSLFALVGGDVGQM
KHWMHTANRHTGGVPAEQVRSVQGLVGVVEYLDAMRGKI

Download         Length: 360 bp

>AT194169 NZ_CP093374:c48976-48746 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References