Detailed information of TA system TA194168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1096516..1097192
• Replicon: chromosome
• Accession: NZ_CP070491
• Organism: Methylococcus sp. EFPC2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JWZ97_RS04780
• Protein ID: WP_205433672.1
• Coordinates: 1096516..1096917 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JWZ97_RS04785
• Protein ID: WP_205433673.1
• Coordinates: 1096920..1097192 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWZ97_RS04765	1091881..1092897	-	1017	WP_205433669.1	conjugal transfer protein TraF	-
JWZ97_RS04770	1092999..1093430	-	432	WP_205433670.1	YkgJ family cysteine cluster protein	-
JWZ97_RS04775	1093454..1096495	-	3042	WP_205433671.1	DEAD/DEAH box helicase family protein	-
JWZ97_RS04780	1096516..1096917	-	402	WP_205433672.1	PIN domain-containing protein	Toxin
JWZ97_RS04785	1096920..1097192	-	273	WP_205433673.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JWZ97_RS04790	1097272..1098648	-	1377	WP_205433674.1	hypothetical protein	-
JWZ97_RS04795	1098645..1100633	-	1989	WP_205433675.1	N-6 DNA methylase	-
JWZ97_RS04800	1100639..1101631	-	993	WP_205433676.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	984821..1106367	121546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

• SpoVT-AbrB domain (10-37)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14700.27 Da
• Isoelectric Point: 8.8957

>T194168 WP_205433672.1 NZ_CP070491:c1096917-1096516 [Methylococcus sp. EFPC2]
VLHMLDTDIASYVIKGRSPVVEAKLMAIVPSMVCISAVTRAELMYGLKRLPAGHRLQLAVRQFLKIVRVLSWDAEAADYY
ADIRHQLVSSGQPIGEMDMMIAAHSLSAGSVLVTNNVRHYSRIEAPLTLVNWA

Nucleotide

• Length: 402 bp

>T194168 NZ_CP093374:28882-29364 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10179.33 Da
• Isoelectric Point: 4.1283

>AT194168 WP_205433673.1 NZ_CP070491:c1097192-1096920 [Methylococcus sp. EFPC2]
MPETRIAKLFKNGASQAVRLPAEFRFEGDEVYATRDEATGDVVLSSRPGAKTWGDFFEMLHSIEVPEDFMEDRPMNAVPV
ERDVFGDEEP

Nucleotide

• Length: 273 bp

>AT194168 NZ_CP093374:28607-28891 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA