Detailed information of TA system TA194167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 985531..987028
• Replicon: chromosome
• Accession: NZ_CP070491
• Organism: Methylococcus sp. EFPC2

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: JWZ97_RS04270
• Protein ID: WP_205433578.1
• Coordinates: 985766..987028 (+)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: JWZ97_RS04265
• Protein ID: WP_205434549.1
• Coordinates: 985531..985776 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWZ97_RS04240	981213..981818	-	606	WP_205433574.1	GNAT family N-acetyltransferase	-
JWZ97_RS04245	981824..982231	-	408	WP_205433575.1	nuclear transport factor 2 family protein	-
JWZ97_RS04250	982604..983161	+	558	WP_205433576.1	tRNA adenosine(34) deaminase TadA	-
JWZ97_RS04255	983177..984577	-	1401	WP_205433577.1	membrane-bound lytic murein transglycosylase MltF	-
JWZ97_RS04265	985531..985776	+	246	WP_205434549.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
JWZ97_RS04270	985766..987028	+	1263	WP_205433578.1	HipA domain-containing protein	Toxin
JWZ97_RS04275	987319..988266	-	948	WP_205433579.1	toprim domain-containing protein	-
JWZ97_RS04280	988378..988896	-	519	WP_205433580.1	hypothetical protein	-
JWZ97_RS04285	989081..989536	-	456	WP_205433581.1	hypothetical protein	-
JWZ97_RS04290	989533..989781	-	249	WP_205433582.1	hypothetical protein	-
JWZ97_RS04295	989892..990224	-	333	WP_205433583.1	hypothetical protein	-
JWZ97_RS04300	990327..990815	-	489	WP_205433584.1	DNA repair protein RadC	-
JWZ97_RS04305	990985..991470	+	486	WP_205433585.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	984821..1106367	121546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 46525.64 Da
• Isoelectric Point: 7.1862

>T194167 WP_205433578.1 NZ_CP070491:985766-987028 [Methylococcus sp. EFPC2]
MARELEVWLFSDRVGILALIDGRLSFRYADPWLKQPNALALSCSLPLQTEPFDDHRARPFFAGLLPEGRLRRLIAQQLQV
SGQNDFGLLDRIGGECAGAVTLLELGNSPNPAGEGEIEWLSDEAVIALLDELPRRPMLAGRDGLRLSLAGVQDKLPVVVD
GDRIGLPRHGTPSSHILKPAIHGVEDSVTNEGFCLALAEALQIIAARSKIQSILDRRFLLVERYDRTSDGSRRIHRWHQE
DFCQALGVVPEMKYQNEGGPDLAQCFELVRRATRPSAPQVLRLLDYVAFNTLIGNHDAHAKNFSLLYAGMAPVLAPLYDA
LSTAVYSDLTPKMAMKPGSKYPFGEVQARHWDQFAEAAGLAKAQTRKRVLELAKRLPVIARKLQAAPEFAGRTIVERIMV
LIEQRAELTVQRLTAPMADV

Nucleotide

• Length: 1263 bp

>T194167 NZ_CP093374:14785-15117 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8572.93 Da
• Isoelectric Point: 9.4962

>AT194167 WP_205434549.1 NZ_CP070491:985531-985776 [Methylococcus sp. EFPC2]
MINIRSTQQLGQALRIARKQLGLTQSQLALAAGCGLRFIVDLEAGKPTLRLETVLRVIESLGGELSLSGLPTATSRSDDG
P

Nucleotide

• Length: 246 bp

>AT194167 NZ_CP093374:14527-14784 [Salmonella enterica subsp. enterica serovar Infantis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA