Detailed information of TA system TA194164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1417504..1418420
• Replicon: chromosome
• Accession: NZ_CP070483
• Organism: Bacillus sp. LJBS06

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: JQX68_RS07355
• Protein ID: WP_095431469.1
• Coordinates: 1417674..1418420 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: G4NV07
• Locus tag: JQX68_RS07350
• Protein ID: WP_003239095.1
• Coordinates: 1417504..1417674 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQX68_RS07315	1414368..1414694	+	327	WP_014663662.1	XkdW family protein	-
JQX68_RS07320	1414691..1414855	+	165	WP_040083360.1	XkdX family protein	-
JQX68_RS07325	1414900..1415739	+	840	WP_040083359.1	hypothetical protein	-
JQX68_RS07330	1415792..1416061	+	270	WP_205440611.1	hemolysin XhlA family protein	-
JQX68_RS07335	1416074..1416337	+	264	WP_003232653.1	phage holin	-
JQX68_RS07340	1416350..1417243	+	894	WP_205440612.1	N-acetylmuramoyl-L-alanine amidase	-
JQX68_RS07345	1417281..1417418	-	138	WP_136654612.1	three component toxin-antitoxin-antitoxin system antitoxin SpoIISC	-
JQX68_RS07350	1417504..1417674	-	171	WP_003239095.1	three component toxin-antitoxin-antitoxin system antitoxin SpoIISB	Antitoxin
JQX68_RS07355	1417674..1418420	-	747	WP_095431469.1	toxin-antitoxin-antitoxin system toxin SpoIISA	Toxin
JQX68_RS07360	1418530..1419531	-	1002	WP_014663667.1	inorganic phosphate transporter family protein	-
JQX68_RS07365	1419544..1420161	-	618	WP_003218470.1	DUF47 domain-containing protein	-
JQX68_RS07370	1420438..1421754	-	1317	WP_136654611.1	serine/threonine exchanger	-
JQX68_RS07375	1422142..1423092	+	951	WP_134975631.1	ring-cleaving dioxygenase	-
JQX68_RS07380	1423177..1423322	+	146	Protein_1391	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-56)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29070.57 Da
• Isoelectric Point: 4.6145

>T194164 WP_095431469.1 NZ_CP070483:c1418420-1417674 [Bacillus sp. LJBS06]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWDRYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CQYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKMVLIPFTIETKNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Nucleotide

• Length: 747 bp

>T194164 NZ_CP093373:c4294865-4294380 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6555.59 Da
• Isoelectric Point: 10.8401

>AT194164 WP_003239095.1 NZ_CP070483:c1417674-1417504 [Bacillus sp. LJBS06]
MERAFQNGCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Nucleotide

• Length: 171 bp

>AT194164 NZ_CP093373:c4295140-4294853 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: G4NV07