Detailed information of TA system TA194151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2825865..2826679
• Replicon: chromosome
• Accession: NZ_CP070482
• Organism: Escherichia coli strain BTH101

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: JWV29_RS13765
• Protein ID: WP_001054376.1
• Coordinates: 2825865..2826122 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: JWV29_RS13770
• Protein ID: WP_001309181.1
• Coordinates: 2826134..2826679 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWV29_RS13740 (2821153)	2821153..2822259	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
JWV29_RS13745 (2822324)	2822324..2823304	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JWV29_RS13750 (2823414)	2823414..2823619	+	206	Protein_2699	HNH endonuclease	-
JWV29_RS13755 (2823887)	2823887..2825127	-	1241	Protein_2700	helicase YjhR	-
JWV29_RS13760 (2825243)	2825243..2825374	+	132	WP_001309182.1	hypothetical protein	-
JWV29_RS13765 (2825865)	2825865..2826122	+	258	WP_001054376.1	YjhX family toxin	Toxin
JWV29_RS13770 (2826134)	2826134..2826679	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
JWV29_RS13775 (2826735)	2826735..2827481	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
JWV29_RS13780 (2827650)	2827650..2827868	+	219	Protein_2705	hypothetical protein	-
JWV29_RS13785 (2827906)	2827906..2828022	+	117	Protein_2706	VOC family protein	-
JWV29_RS13790 (2828267)	2828267..2829388	+	1122	WP_000010829.1	M42 family metallopeptidase	-
JWV29_RS13795 (2829385)	2829385..2829663	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
JWV29_RS13800 (2829675)	2829675..2830988	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	2815651..2834903	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T194151 WP_001054376.1 NZ_CP070482:2825865-2826122 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T194151 NZ_CP093369:c3863061-3862654 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT194151 WP_001309181.1 NZ_CP070482:2826134-2826679 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT194151 NZ_CP093369:c3863308-3863042 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8