Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1221891..1222529 Replicon chromosome
Accession NZ_CP070482
Organism Escherichia coli strain BTH101

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JWV29_RS05945 Protein ID WP_000813794.1
Coordinates 1222353..1222529 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JWV29_RS05940 Protein ID WP_001270286.1
Coordinates 1221891..1222307 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWV29_RS05920 (1217043) 1217043..1217984 - 942 WP_001251304.1 ABC transporter permease -
JWV29_RS05925 (1217985) 1217985..1218998 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JWV29_RS05930 (1219016) 1219016..1220161 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JWV29_RS05935 (1220406) 1220406..1221812 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JWV29_RS05940 (1221891) 1221891..1222307 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JWV29_RS05945 (1222353) 1222353..1222529 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JWV29_RS05950 (1222751) 1222751..1222981 + 231 WP_000494244.1 YncJ family protein -
JWV29_RS05955 (1223073) 1223073..1225034 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JWV29_RS05960 (1225107) 1225107..1225643 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JWV29_RS05965 (1225696) 1225696..1226910 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T194144 WP_000813794.1 NZ_CP070482:c1222529-1222353 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T194144 NZ_CP093369:c2745477-2745374 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT194144 WP_001270286.1 NZ_CP070482:c1222307-1221891 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT194144 NZ_CP093369:2745336-2745607 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References