194126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1880905..1881513 Replicon chromosome
Accession NZ_CP070471
Organism Pseudomonas aeruginosa strain B17932

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag JT750_RS08605 Protein ID WP_019486378.1
Coordinates 1881166..1881513 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag JT750_RS08600 Protein ID WP_003114155.1
Coordinates 1880905..1881156 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT750_RS08580 1876543..1876899 + 357 WP_003114150.1 DUF2523 domain-containing protein -
JT750_RS08585 1876903..1878186 + 1284 WP_023124144.1 zonular occludens toxin family protein -
JT750_RS08590 1878416..1879708 + 1293 WP_003123045.1 hypothetical protein -
JT750_RS08595 1879708..1880691 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
JT750_RS08600 1880905..1881156 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JT750_RS08605 1881166..1881513 + 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT750_RS08615 1881840..1882742 - 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
JT750_RS08620 1883194..1883931 - 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
JT750_RS08625 1884011..1885054 - 1044 WP_003134392.1 L,D-transpeptidase -
JT750_RS08630 1885190..1885882 - 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
JT750_RS08635 1885882..1886154 - 273 WP_074241374.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 1860822..1890601 29779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T194126 WP_019486378.1 NZ_CP070471:1881166-1881513 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T194126 NZ_CP093368:3606157-3606486 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT194126 WP_003114155.1 NZ_CP070471:1880905-1881156 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT194126 NZ_CP093368:3605819-3606136 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References