194123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 270773..271278 Replicon chromosome
Accession NZ_CP070471
Organism Pseudomonas aeruginosa strain B17932

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag JT750_RS01335 Protein ID WP_031640969.1
Coordinates 270773..271054 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag JT750_RS01340 Protein ID WP_003083775.1
Coordinates 271051..271278 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT750_RS01310 266024..267373 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
JT750_RS01315 267422..268108 + 687 WP_003083762.1 FadR family transcriptional regulator -
JT750_RS01320 268209..268943 + 735 WP_003128333.1 GntR family transcriptional regulator -
JT750_RS01325 269147..269533 + 387 WP_003083767.1 aegerolysin family protein -
JT750_RS01330 269565..270473 - 909 WP_033990895.1 LysR family transcriptional regulator -
JT750_RS01335 270773..271054 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
JT750_RS01340 271051..271278 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
JT750_RS01345 271454..272074 - 621 WP_003101226.1 hypothetical protein -
JT750_RS01350 272175..272675 + 501 WP_003101228.1 LEA type 2 family protein -
JT750_RS01355 272747..273088 + 342 WP_003101229.1 alkylphosphonate utilization protein -
JT750_RS01360 273170..274597 - 1428 WP_003083784.1 GABA permease -
JT750_RS01365 274766..276259 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T194123 WP_031640969.1 NZ_CP070471:c271054-270773 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T194123 NZ_CP093368:c2943764-2943510 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT194123 WP_003083775.1 NZ_CP070471:c271278-271051 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT194123 NZ_CP093368:c2944012-2943761 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References