Detailed information of TA system TA194122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 178307..178875
• Replicon: chromosome
• Accession: NZ_CP070471
• Organism: Pseudomonas aeruginosa strain B17932

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0D0R3P1
• Locus tag: JT750_RS00885
• Protein ID: WP_011222050.1
• Coordinates: 178307..178600 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6M3UV67
• Locus tag: JT750_RS00890
• Protein ID: WP_011222051.1
• Coordinates: 178588..178875 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT750_RS00855	173555..174454	+	900	WP_032494864.1	class A extended-spectrum beta-lactamase VEB-9	-
JT750_RS00860	175188..176378	-	1191	WP_033991588.1	tetracycline efflux MFS transporter Tet(A)	-
JT750_RS00865	176484..177134	+	651	WP_000164043.1	tetracycline resistance transcriptional repressor TetR(A)	-
JT750_RS00870	177166..177408	-	243	WP_000844627.1	transposase	-
JT750_RS00875	177837..178022	+	186	Protein_174	multidrug transporter	-
JT750_RS00880	178058..178369	+	312	WP_052150402.1	hypothetical protein	-
JT750_RS00885	178307..178600	-	294	WP_011222050.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT750_RS00890	178588..178875	-	288	WP_011222051.1	CopG family ribbon-helix-helix protein	Antitoxin
JT750_RS00895	179048..179254	-	207	WP_033991586.1	hypothetical protein	-
JT750_RS00900	179489..181168	+	1680	WP_000179844.1	DDE-type integrase/transposase/recombinase	-
JT750_RS00905	181171..182163	+	993	WP_001381192.1	TniB family NTP-binding protein	-
JT750_RS00910	182132..182632	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
JT750_RS00915	182760..183599	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaOXA-10 / ant(3'')-Ia / sul1 / blaNDM-1 / blaVEB-1 / tet(A) / aph(3')-VI	-	101461..208406	106945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10890.71 Da
• Isoelectric Point: 10.8518

>T194122 WP_011222050.1 NZ_CP070471:c178600-178307 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Nucleotide

• Length: 294 bp

>T194122 NZ_CP093368:2931868-2932242 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10922.19 Da
• Isoelectric Point: 5.1897

>AT194122 WP_011222051.1 NZ_CP070471:c178875-178588 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Nucleotide

• Length: 288 bp

>AT194122 NZ_CP093368:2931411-2931779 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A0D0R3P1

Antitoxin

• AlphaFold DB: A0A6M3UV67