Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4759306..4759822 Replicon chromosome
Accession NZ_CP070464
Organism Klebsiella pneumoniae strain B28906

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag JT748_RS22925 Protein ID WP_004894697.1
Coordinates 4759306..4759590 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JT748_RS22930 Protein ID WP_002886901.1
Coordinates 4759580..4759822 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT748_RS22900 4754701..4755009 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
JT748_RS22905 4755094..4755267 + 174 WP_002886906.1 hypothetical protein -
JT748_RS22910 4755270..4756013 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
JT748_RS22915 4756371..4758509 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
JT748_RS22920 4758838..4759302 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JT748_RS22925 4759306..4759590 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT748_RS22930 4759580..4759822 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JT748_RS22935 4759900..4761810 - 1911 WP_023325426.1 BglG family transcription antiterminator -
JT748_RS22940 4761833..4762987 - 1155 WP_004178372.1 lactonase family protein -
JT748_RS22945 4763054..4763794 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T194118 WP_004894697.1 NZ_CP070464:c4759590-4759306 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194118 NZ_CP093368:2363913-2364089 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194118 WP_002886901.1 NZ_CP070464:c4759822-4759580 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194118 NZ_CP093368:2364135-2364551 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References