Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4023972..4024591 Replicon chromosome
Accession NZ_CP070464
Organism Klebsiella pneumoniae strain B28906

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JT748_RS19420 Protein ID WP_002892050.1
Coordinates 4024373..4024591 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JT748_RS19415 Protein ID WP_002892066.1
Coordinates 4023972..4024346 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT748_RS19405 4019124..4020317 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JT748_RS19410 4020340..4023486 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JT748_RS19415 4023972..4024346 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JT748_RS19420 4024373..4024591 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JT748_RS19425 4024750..4025316 + 567 WP_002892030.1 maltose O-acetyltransferase -
JT748_RS19430 4025288..4025428 - 141 WP_032409038.1 hypothetical protein -
JT748_RS19435 4025449..4025919 + 471 WP_002892026.1 YlaC family protein -
JT748_RS19440 4025894..4027345 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JT748_RS19445 4027446..4028144 + 699 WP_004893822.1 GNAT family N-acetyltransferase -
JT748_RS19450 4028141..4028281 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JT748_RS19455 4028281..4028544 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194116 WP_002892050.1 NZ_CP070464:4024373-4024591 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194116 NZ_CP093368:c2148696-2148589 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194116 WP_002892066.1 NZ_CP070464:4023972-4024346 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194116 NZ_CP093368:2148743-2148809 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References