Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 104249..104988 Replicon plasmid p1B25110
Accession NZ_CP070455
Organism Klebsiella quasipneumoniae strain B25110

Toxin (Protein)


Gene name tacT Uniprot ID J6I5J9
Locus tag JT746_RS26670 Protein ID WP_009653238.1
Coordinates 104249..104734 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID J5VA20
Locus tag JT746_RS26675 Protein ID WP_009653219.1
Coordinates 104722..104988 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT746_RS26630 99428..99748 - 321 WP_004152720.1 type II toxin-antitoxin system RelE/ParE family toxin -
JT746_RS26635 99829..100053 - 225 WP_004152719.1 hypothetical protein -
JT746_RS26640 100064..100276 - 213 WP_004152718.1 hypothetical protein -
JT746_RS26645 100337..100693 - 357 WP_004152717.1 hypothetical protein -
JT746_RS26650 101330..101680 - 351 WP_023280874.1 hypothetical protein -
JT746_RS26655 101677..101949 - 273 WP_023280873.1 hypothetical protein -
JT746_RS26660 102645..102806 - 162 WP_004118124.1 type I toxin-antitoxin system Hok family toxin -
JT746_RS26665 102876..103955 + 1080 WP_009653230.1 IS481 family transposase -
JT746_RS26670 104249..104734 - 486 WP_009653238.1 GNAT family N-acetyltransferase Toxin
JT746_RS26675 104722..104988 - 267 WP_009653219.1 DUF1778 domain-containing protein Antitoxin
JT746_RS26680 105228..105593 + 366 WP_029602878.1 hypothetical protein -
JT746_RS26685 105638..106375 + 738 WP_009654087.1 HupE/UreJ family protein -
JT746_RS26690 106389..107078 + 690 WP_009654088.1 hypothetical protein -
JT746_RS26695 107219..107590 + 372 WP_029602876.1 hypothetical protein -
JT746_RS26700 107654..108574 + 921 WP_009651631.1 hypothetical protein -
JT746_RS26705 108628..109386 + 759 WP_023303135.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..134891 134891
- flank IS/Tn - - 102876..103955 1079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-150)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.9000

>T194085 WP_009653238.1 NZ_CP070455:c104734-104249 [Klebsiella quasipneumoniae]
VGYVTSPEPLSSFHQVAEFISGEAVLDDWLKQRSLKNQATGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCFRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQSQPRTLFLRLP
Q

Download         Length: 486 bp

>T194085 NZ_CP093356:2814708-2815283 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.58 Da        Isoelectric Point: 4.4128

>AT194085 WP_009653219.1 NZ_CP070455:c104988-104722 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDEQYAEFIDMIDAPVADDPAIEKLL
ARKPQWDM

Download         Length: 267 bp

>AT194085 NZ_CP093356:2814241-2814711 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCGTTGCGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142I4R1

Antitoxin

Source ID Structure
AlphaFold DB A0A142I4R0

References