Detailed information of TA system TA194082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4858919..4859432
• Replicon: chromosome
• Accession: NZ_CP070454
• Organism: Klebsiella quasipneumoniae strain B25110

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JT746_RS23515
• Protein ID: WP_109546715.1
• Coordinates: 4858919..4859200 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JT746_RS23520
• Protein ID: WP_023319595.1
• Coordinates: 4859190..4859432 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT746_RS23505	4855917..4858055	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
JT746_RS23510	4858451..4858915	+	465	WP_109546714.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JT746_RS23515	4858919..4859200	-	282	WP_109546715.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT746_RS23520	4859190..4859432	-	243	WP_023319595.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JT746_RS23525	4859510..4861420	-	1911	WP_109546716.1	BglG family transcription antiterminator	-
JT746_RS23530	4861443..4862597	-	1155	WP_109546717.1	lactonase family protein	-
JT746_RS23535	4862664..4863404	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10982.81 Da
• Isoelectric Point: 10.4134

>T194082 WP_109546715.1 NZ_CP070454:c4859200-4858919 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLNDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T194082 NZ_CP093356:c141449-141168 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGAAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9089.55 Da
• Isoelectric Point: 4.8146

>AT194082 WP_023319595.1 NZ_CP070454:c4859432-4859190 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT194082 NZ_CP093356:c141673-141446 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCGGAGATCGAGAAGCGCTGGGGGCTGCAATGA