Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4058368..4058987 Replicon chromosome
Accession NZ_CP070449
Organism Klebsiella pneumoniae strain B18064

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JT745_RS19915 Protein ID WP_002892050.1
Coordinates 4058769..4058987 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JT745_RS19910 Protein ID WP_002892066.1
Coordinates 4058368..4058742 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT745_RS19900 4053520..4054713 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JT745_RS19905 4054736..4057882 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JT745_RS19910 4058368..4058742 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JT745_RS19915 4058769..4058987 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JT745_RS19920 4059150..4059716 + 567 WP_002892030.1 maltose O-acetyltransferase -
JT745_RS19925 4059688..4059828 - 141 WP_004147370.1 hypothetical protein -
JT745_RS19930 4059849..4060319 + 471 WP_002892026.1 YlaC family protein -
JT745_RS19935 4060294..4061745 - 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
JT745_RS19940 4061846..4062544 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
JT745_RS19945 4062541..4062681 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JT745_RS19950 4062681..4062944 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194066 WP_002892050.1 NZ_CP070449:4058769-4058987 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194066 NZ_CP093337:983784-984053 [Shinella sp. H4-D48]
TTGGCCTGGGCGATTGAGATCACCGAAGGGGCTAAGAAAGAGCTCGATAAACTCGGTCATGTCGAGGCAAAGCGCATTCT
TAATTTTCTTGTCACGAAGCTTGCTTCCTCGGAAAATCCTCGCCTGCTGGGCAGCGCTTTGCAGGGCGCGCGGCTGGGAA
GCTATTGGCGGTATCGCGTTGGCGACTATCGGATCATTTGTGACATCCAGGACAACAGGCTTGTCGTGGTTGTCGTTCGT
GTAGGACATCGGCGTGAAATATATTCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194066 WP_002892066.1 NZ_CP070449:4058368-4058742 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194066 NZ_CP093337:983567-983800 [Shinella sp. H4-D48]
ATGGCGAGACAGACGGCAATCCGACTTCCTGACGAGACCTATGAGCGGCTGCAGGCGTTGGCCGCGCGGACTGGGCGCAC
AGCGACATATTACATTCGCGAGGCCATTGAACAGCATATCGAGGATCTCGAGGATATTTATCTCGCGGAGCAGGAACTTG
AGCACGTGCGGCGTGGCGAAAGCCGTGTCTATTCTCTGAAGGAGGTTGAGGACGAGCTTGGCCTGGGCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References