Detailed information of TA system TA194055

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 792271..792928
• Replicon: chromosome
• Accession: NZ_CP070449
• Organism: Klebsiella pneumoniae strain B18064

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JT745_RS03930
• Protein ID: WP_040245400.1
• Coordinates: 792518..792928 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: JT745_RS03925
• Protein ID: WP_002916312.1
• Coordinates: 792271..792537 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT745_RS03900	787427..788860	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
JT745_RS03905	788979..789707	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
JT745_RS03910	789757..790068	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
JT745_RS03915	790232..790891	+	660	WP_048334397.1	hemolysin III family protein	-
JT745_RS03920	791042..792025	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
JT745_RS03925	792271..792537	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
JT745_RS03930	792518..792928	+	411	WP_040245400.1	protein YgfX	Toxin
JT745_RS03935	792935..793456	-	522	WP_002916308.1	flavodoxin FldB	-
JT745_RS03940	793557..794453	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
JT745_RS03945	794476..795189	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JT745_RS03950	795195..796928	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T194055 WP_040245400.1 NZ_CP070449:792518-792928 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T194055 NZ_CP093334:3978990-3979400 [Raoultella planticola]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGCTCGCAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTCCTGCTGATGCCCTGGCCGCTGAGCTACACACCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGTGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGCCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGGTCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTTTTACAAAAACCGG
CACAGGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT194055 WP_002916312.1 NZ_CP070449:792271-792537 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT194055 NZ_CP093334:3978743-3979009 [Raoultella planticola]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGCCTGTTAGAAAACGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCACAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41