Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4785498..4786014 Replicon chromosome
Accession NZ_CP070445
Organism Klebsiella pneumoniae strain B12097

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JT744_RS23335 Protein ID WP_040216106.1
Coordinates 4785498..4785782 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JT744_RS23340 Protein ID WP_064162488.1
Coordinates 4785772..4786014 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT744_RS23310 4780915..4781223 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JT744_RS23315 4781308..4781481 + 174 WP_032425422.1 hypothetical protein -
JT744_RS23320 4781484..4782227 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JT744_RS23325 4782584..4784722 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JT744_RS23330 4785030..4785494 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JT744_RS23335 4785498..4785782 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT744_RS23340 4785772..4786014 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JT744_RS23345 4786092..4788002 - 1911 WP_023325426.1 BglG family transcription antiterminator -
JT744_RS23350 4788025..4789179 - 1155 WP_064162489.1 lactonase family protein -
JT744_RS23355 4789246..4789986 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T194052 WP_040216106.1 NZ_CP070445:c4785782-4785498 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194052 NZ_CP093333:3623838-3624188 [Pseudomonas simiae]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCACGGTTT
TCAACAGGCGTTGATGAAGAACCCGGAAGCGGGAGACGTGATCGAGGGAACAGGCGGGTTACGCAAGGTTAGCTTTGTCG
ACGAACGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCAGACGGCACGCAATTCTGGTTA
TTCACCCTGTACGGCAAACACGAACAGGACGACCTGACGCCTCAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT194052 WP_064162488.1 NZ_CP070445:c4786014-4785772 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194052 NZ_CP093333:3624178-3624492 [Pseudomonas simiae]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCAAACGAACGCCAAGGCAAAGTCACCCTGCG
GACCCACAAGGTTCATCTCAACAACCTGGAGCCGCTCACCGCAGAGGAAGTGGTCGCCGTGCGTCAACAGCTCAACCTCT
CCCGTGCCGTCTTCGCCATGTACCTGCGCACCAACACGCGTACGCTGGAGAACTGGGAGCAAGGCCGGGCTAAACCAAAT
GCCCAGGCCGCCACCCTGATTCGCCTGGTGGCGCGTTTTCCTGAGACCGTGGCACAACTTGCTGCGTTGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References