Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4049767..4050386 Replicon chromosome
Accession NZ_CP070445
Organism Klebsiella pneumoniae strain B12097

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JT744_RS19855 Protein ID WP_002892050.1
Coordinates 4050168..4050386 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JT744_RS19850 Protein ID WP_002892066.1
Coordinates 4049767..4050141 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT744_RS19840 4044919..4046112 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JT744_RS19845 4046135..4049281 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JT744_RS19850 4049767..4050141 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JT744_RS19855 4050168..4050386 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JT744_RS19860 4050549..4051115 + 567 WP_002892030.1 maltose O-acetyltransferase -
JT744_RS19865 4051087..4051227 - 141 WP_004147370.1 hypothetical protein -
JT744_RS19870 4051248..4051718 + 471 WP_002892026.1 YlaC family protein -
JT744_RS19875 4051693..4053144 - 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
JT744_RS19880 4053245..4053943 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
JT744_RS19885 4053940..4054080 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JT744_RS19890 4054080..4054343 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194050 WP_002892050.1 NZ_CP070445:4050168-4050386 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194050 NZ_CP093332:4090833-4091051 [Buttiauxella ferragutiae]
ATGACTACTAAACCATTAACTAAGACTGATTATTTGATGCGTCTGCGACGCTGCCAAACAATTGAGACCTTAGAACGTGT
AATTGAAAAAAATAAATACGAATTATCAGATAATGAATTGGCGGTATTTTATTCAGCTGCCGACCACCGACTTGCTGAAC
TCACCATGAATAAGCTTTACGATAAAATACCACCCTCTGTATGGACATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194050 WP_002892066.1 NZ_CP070445:4049767-4050141 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194050 NZ_CP093332:4090429-4090803 [Buttiauxella ferragutiae]
ATGGACGAATACTCACCAAAACGGCATGATATTGCGCAGCTTAAATTTCTCTGCGAAAACCTGTATCATGACTGCCTTAC
CAACCTTGGCGAGAGTAATCATGGTTGGGTTAATGATCCTACTTCGGCCATTAACTTGCAGTTGAATGAATTGATTGAGC
ACATAGCTGCCTTCGCACTTAATTACAAAATTAAGTATGATGATGAGAGTAAATTGATTGAACAAATTGACGAATATTTG
GACGATACCTTTATGCTGTTCAGCAACTACGGCATCAATGCACACGATTTGCAGAAATGGCGTAAGTCCGGGAATCGATT
ATTCCGATGTTTCGTCACAGAGAGCCGCGCTAACCCTGTAAGCCTCTCCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References