Detailed information of TA system TA194048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2669849..2671437
• Replicon: chromosome
• Accession: NZ_CP070445
• Organism: Klebsiella pneumoniae strain B12097

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JT744_RS13040
• Protein ID: WP_064162061.1
• Coordinates: 2669849..2671171 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: JT744_RS13045
• Protein ID: WP_002904790.1
• Coordinates: 2671171..2671437 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT744_RS13025	2664905..2667406	+	2502	WP_064162059.1	fimbrial biogenesis outer membrane usher protein	-
JT744_RS13030	2667394..2668398	+	1005	WP_064162060.1	type 1 fimbrial protein	-
JT744_RS13035	2668540..2669832	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
JT744_RS13040	2669849..2671171	-	1323	WP_064162061.1	type II toxin-antitoxin system HipA family toxin	Toxin
JT744_RS13045	2671171..2671437	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JT744_RS13050	2671703..2672029	-	327	WP_064162062.1	hydroxyisourate hydrolase	-
JT744_RS13055	2672026..2672526	-	501	WP_064162063.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JT744_RS13060	2672504..2673883	-	1380	WP_040245186.1	purine permease	-
JT744_RS13065	2674229..2675383	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
JT744_RS13070	2675364..2676287	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49155.46 Da
• Isoelectric Point: 7.5357

>T194048 WP_064162061.1 NZ_CP070445:c2671171-2669849 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T194048 NZ_CP093332:c2972923-2972591 [Buttiauxella ferragutiae]
ATGGTTTCACGTTTTGTACCGGATTCTGGCGATGTTATCTGGATTGATTTTGACCATGTAGCAGGACACGAACAGGGCGG
TAATCGCCCTGCCGTGGTGCTGAGCCCATTTGCATATAATAATAAAGTGGGTTTACTACTCTGCGTTCCCTGTACAACCA
AAGCAAAAGACTATCCGTTTGAGGTTGAACTCTCTGGCGAACGTGAAAGCGTAGCCCTGGCCGATCAAATCACATGCGTT
GATTGGCGAGCCAGAAAGGTGACAAAAAAGGGAAGCGTTAGTGTTGCCGAACTGGCTGATATAAGGGCTAAAGCAAAAAC
ACTCATTGGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT194048 WP_002904790.1 NZ_CP070445:c2671437-2671171 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT194048 NZ_CP093332:c2973168-2972923 [Buttiauxella ferragutiae]
ATGTCGAAGGTAATAGTGAAAAAATGGGGTAACAGCCCATCCGTACGGCTTCCTGTGGCCATTATGCAAGCGGCATCATT
GAATGTGGATGATACCGTTGATATTTCGGTTGAAGACGGCCGTATTGTCATTGTACCGGTGAAAACGAAGGAATATTCCC
TTGATGCGCTGTTAGCCGGGATTACTCCTGACAACATCCATGAAAAAGTTGATTTTGGCGCTCCGGTCGGTAAGGAGCTG
ATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8