Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 85543..86068 Replicon plasmid p1B9067
Accession NZ_CP070441
Organism Klebsiella quasipneumoniae strain B9067

Toxin (Protein)


Gene name ccdB Uniprot ID W8UQV6
Locus tag JT742_RS26540 Protein ID WP_001568026.1
Coordinates 85763..86068 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag JT742_RS26535 Protein ID WP_001568025.1
Coordinates 85543..85761 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT742_RS26505 81179..82576 - 1398 WP_032452481.1 diguanylate cyclase -
JT742_RS26510 82797..83494 - 698 Protein_78 IS1 family transposase -
JT742_RS26515 83528..84238 - 711 WP_004152334.1 ATP-binding protein -
JT742_RS26520 84312..84728 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin -
JT742_RS26525 84725..84955 - 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JT742_RS26530 84912..85373 + 462 Protein_82 hypothetical protein -
JT742_RS26535 85543..85761 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JT742_RS26540 85763..86068 + 306 WP_001568026.1 type II toxin-antitoxin system toxin CcdB Toxin
JT742_RS26545 86237..86632 + 396 WP_072158608.1 hypothetical protein -
JT742_RS26550 86659..86982 + 324 WP_022644730.1 hypothetical protein -
JT742_RS26555 86979..87995 + 1017 WP_020315256.1 hypothetical protein -
JT742_RS26560 88148..88852 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
JT742_RS26565 88906..89280 - 375 Protein_89 DUF86 domain-containing protein -
JT742_RS26570 89277..89567 - 291 WP_001247892.1 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..134890 134890
- inside IScluster/Tn - - 70045..92530 22485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11645.32 Da        Isoelectric Point: 5.6919

>T194036 WP_001568026.1 NZ_CP070441:85763-86068 [Klebsiella quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T194036 NZ_CP093328:2854858-2855040 [Rahnella aceris]
ATGAAATCAACGGAATTGATTAAAGCGCTGCTTGCAGCGGGTTGTGAACTCAAGCGTCACCGGGGAGGAAGTCATCAAAT
TTGGTGGTCACCTGTCACCAACAAAACCTTTCCCGTTCCCCACCCCAAAAATGATTTACCTGTGGGAACTCTCAAATCCA
TTAGAAAAATGGCAGGGATATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT194036 WP_001568025.1 NZ_CP070441:85543-85761 [Klebsiella quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT194036 NZ_CP093328:2855062-2855493 [Rahnella aceris]
ATGTTCTTTTCAGTCGGTCTTGAAACACCAAAAGATGACAAAACCGCTTACGGTATGGTGGTACCTGCATTTACCGCGTT
TGATTACGGATGCTTCTCTGCAGCGGATACCCGTGAAGAAATCGCCCCTATGGTTCGCGAAGCCATCCTGATGACAGTAG
AAGATTTGATCGAAAGCGAACGCTTTGTTGTTGACGATATTTTTGATGCAGGCCATTTGGTGTATGCCGCTAATCCCGAA
TATGCCGACTTCGATACCTGGTTTTTGATTGATATTGATCTCTCGGAATTCGAAGGGAAAGCGCATCGAATCAATATTTC
GCTGCCTGACACCCTGATCAAACGCATTGATAATAAAGTTAAAAATCATCCGTCATATCGCGACCGCAGCCATTTTCTGG
CGATGGCCGCACGTAAAGAATTGCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EZN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References