Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 14444..15189 | Replicon | plasmid p1B5617 |
| Accession | NZ_CP070436 | ||
| Organism | Klebsiella pneumoniae strain B5617 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | JT733_RS26280 | Protein ID | WP_032408901.1 |
| Coordinates | 14698..15189 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | JT733_RS26275 | Protein ID | WP_014386183.1 |
| Coordinates | 14444..14710 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JT733_RS26225 | 9995..10408 | - | 414 | WP_013023817.1 | helix-turn-helix domain-containing protein | - |
| JT733_RS26230 | 10409..10687 | - | 279 | WP_004152721.1 | helix-turn-helix domain-containing protein | - |
| JT733_RS26235 | 10677..10997 | - | 321 | WP_004152720.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JT733_RS26240 | 11078..11302 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| JT733_RS26245 | 11313..11525 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| JT733_RS26250 | 11587..11913 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| JT733_RS26255 | 12551..12901 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| JT733_RS26260 | 12898..13170 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| JT733_RS26265 | 13360..13845 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| JT733_RS26270 | 14089..14247 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| JT733_RS26275 | 14444..14710 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| JT733_RS26280 | 14698..15189 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| JT733_RS26285 | 15630..15881 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| JT733_RS26290 | 16078..17670 | - | 1593 | Protein_28 | IS66 family transposase | - |
| JT733_RS26295 | 17701..18051 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| JT733_RS26300 | 18048..18488 | - | 441 | WP_014386179.1 | IS66 family insertion sequence hypothetical protein | - |
| JT733_RS26305 | 18750..19505 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr | - | 1..151424 | 151424 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T194017 WP_032408901.1 NZ_CP070436:14698-15189 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T194017 NZ_CP093323:c1119073-1118729 [Serratia plymuthica]
ATGTGGCAAGTCGTCACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGGCGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCTCGTCCGCATGCCGACACTTTGCATTTTTCCGGCTCAATAA
AGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGGGTGTTTTTCGCCTTTGATCCGCAACGGCAAGCG
GTATTGCTATGCGGTGGTGATAAAACAGGCGATAAACGCTTTTACCAGCGCCTGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCAGAGGTAA
ATGTGGCAAGTCGTCACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGGCGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCTCGTCCGCATGCCGACACTTTGCATTTTTCCGGCTCAATAA
AGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGGGTGTTTTTCGCCTTTGATCCGCAACGGCAAGCG
GTATTGCTATGCGGTGGTGATAAAACAGGCGATAAACGCTTTTACCAGCGCCTGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCAGAGGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT194017 WP_014386183.1 NZ_CP070436:14444-14710 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT194017 NZ_CP093323:c1118723-1118421 [Serratia plymuthica]
ATGGCCAAGCCTTTATCAAATTTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAATTGCGGCTGGCGATGCTGCGGGAAGAACTTGCGGTATCTCAGGTAGAACTGGCAAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA
ATGGCCAAGCCTTTATCAAATTTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAATTGCGGCTGGCGATGCTGCGGGAAGAACTTGCGGTATCTCAGGTAGAACTGGCAAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|