Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4765465..4765981 Replicon chromosome
Accession NZ_CP070435
Organism Klebsiella pneumoniae strain B5617

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JT733_RS23520 Protein ID WP_002886902.1
Coordinates 4765465..4765749 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JT733_RS23525 Protein ID WP_002886901.1
Coordinates 4765739..4765981 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT733_RS23495 4760881..4761189 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JT733_RS23500 4761274..4761447 + 174 WP_032410138.1 hypothetical protein -
JT733_RS23505 4761450..4762193 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JT733_RS23510 4762550..4764688 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JT733_RS23515 4764997..4765461 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JT733_RS23520 4765465..4765749 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT733_RS23525 4765739..4765981 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JT733_RS23530 4766059..4767969 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JT733_RS23535 4767992..4769146 - 1155 WP_023302389.1 lactonase family protein -
JT733_RS23540 4769213..4769953 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T194014 WP_002886902.1 NZ_CP070435:c4765749-4765465 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194014 NZ_CP093322:c4311465-4311130 [Yersinia intermedia]
ATGAAACCACACCCCACAGCAGCGGGTGCATTGCCCGTATCTGCTATTTATCAACAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAACAGATAGAACAAGGGATTTCAG
TCGGCGACACCGTCAACACCCTGGTTGAAAAATATGCCTTAGTGCGTATTGGCCGCACCGGGTTCAGTGCATTGGCACAA
AACCCCACGCTGAGCAAGGGTGATATCGCCCGTGCTCGCCAGGCCGCAGGGCTGTGGCGAGCACATTTTCCGCCCACGTT
GCTGTACCCCACGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194014 WP_002886901.1 NZ_CP070435:c4765981-4765739 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194014 NZ_CP093322:c4311091-4310759 [Yersinia intermedia]
ATGAATAACAACACGAGCACGTCCCCAGCATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCTACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCTGTGTATCA
GAAACTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References