Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2680147..2681735 Replicon chromosome
Accession NZ_CP070435
Organism Klebsiella pneumoniae strain B5617

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JT733_RS13285 Protein ID WP_023301940.1
Coordinates 2680147..2681469 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JT733_RS13290 Protein ID WP_002904790.1
Coordinates 2681469..2681735 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT733_RS13270 2675203..2677704 + 2502 WP_040182042.1 fimbrial biogenesis outer membrane usher protein -
JT733_RS13275 2677692..2678696 + 1005 WP_009308876.1 type 1 fimbrial protein -
JT733_RS13280 2678838..2680130 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
JT733_RS13285 2680147..2681469 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JT733_RS13290 2681469..2681735 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JT733_RS13295 2682001..2682327 - 327 WP_004143476.1 hydroxyisourate hydrolase -
JT733_RS13300 2682324..2682824 - 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JT733_RS13305 2682802..2684181 - 1380 WP_004176204.1 purine permease -
JT733_RS13310 2684527..2685681 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
JT733_RS13315 2685662..2686585 - 924 WP_205450140.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T194011 WP_023301940.1 NZ_CP070435:c2681469-2680147 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T194011 NZ_CP093322:2168577-2168660 [Yersinia intermedia]
ATTAATGCCAACTTTTAGCGCACGGCTCTGTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGTATTCGGTCTCT
TTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT194011 WP_002904790.1 NZ_CP070435:c2681735-2681469 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT194011 NZ_CP093322:c2168664-2168577 [Yersinia intermedia]
AGATAAAAAGAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGACAGAGCCGTGCGCTAAAAGTTG
GCATTAAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References