Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4792770..4793286 Replicon chromosome
Accession NZ_CP070425
Organism Klebsiella pneumoniae strain B3824

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JT727_RS23395 Protein ID WP_040216106.1
Coordinates 4792770..4793054 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JT727_RS23400 Protein ID WP_064162488.1
Coordinates 4793044..4793286 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT727_RS23370 4788187..4788495 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JT727_RS23375 4788580..4788753 + 174 WP_032425422.1 hypothetical protein -
JT727_RS23380 4788756..4789499 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JT727_RS23385 4789856..4791994 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JT727_RS23390 4792302..4792766 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JT727_RS23395 4792770..4793054 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT727_RS23400 4793044..4793286 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JT727_RS23405 4793364..4795274 - 1911 WP_023325426.1 BglG family transcription antiterminator -
JT727_RS23410 4795297..4796451 - 1155 WP_064162489.1 lactonase family protein -
JT727_RS23415 4796518..4797258 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T193982 WP_040216106.1 NZ_CP070425:c4793054-4792770 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T193982 NZ_CP093317:958141-958476 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGATTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT193982 WP_064162488.1 NZ_CP070425:c4793286-4793044 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT193982 NZ_CP093317:957893-958141 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References