Detailed information of TA system TA193964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4860014..4860527
• Replicon: chromosome
• Accession: NZ_CP070420
• Organism: Klebsiella quasipneumoniae strain B2663

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JT726_RS23520
• Protein ID: WP_109546715.1
• Coordinates: 4860014..4860295 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JT726_RS23525
• Protein ID: WP_023319595.1
• Coordinates: 4860285..4860527 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT726_RS23510	4857012..4859150	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
JT726_RS23515	4859546..4860010	+	465	WP_109546714.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JT726_RS23520	4860014..4860295	-	282	WP_109546715.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT726_RS23525	4860285..4860527	-	243	WP_023319595.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JT726_RS23530	4860605..4862515	-	1911	WP_109546716.1	BglG family transcription antiterminator	-
JT726_RS23535	4862538..4863692	-	1155	WP_109546717.1	lactonase family protein	-
JT726_RS23540	4863759..4864499	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10982.81 Da
• Isoelectric Point: 10.4134

>T193964 WP_109546715.1 NZ_CP070420:c4860295-4860014 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLNDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T193964 NZ_CP093313:c6162882-6162532 [Occallatibacter riparius]
GTGGTGAAGCCGTATGTTCCTGACGCCGGCGACATCGTGATGCTGGACTTCGATCCTCAGGTTGGGCGCGAACAGGCGAA
GCGGCGTCCGGCGCTGGTGCTTACGGATGTGCGGTATAACCGGGCGAGTGGGCTCGCCGTTGTGTGCCCGCTGACTAGTA
AGCGCAAGCCATATCCGTTCGCTCTGCCGATCAATGTGGGTGGAGTTGAGGGCGCGGTGCTGGCCGACCAGCTCAAGAGC
CTGGATTGGGCCGGGCGTCACGCGGACTTCCACTCGAAGGTGGCGCCGGCAATGCTAACCAAAGTACGGCAGTATGTTGC
GGTGTTGCTGGCGATTCCTGTGAAGCCGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9089.55 Da
• Isoelectric Point: 4.8146

>AT193964 WP_023319595.1 NZ_CP070420:c4860527-4860285 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT193964 NZ_CP093313:c6163124-6162876 [Occallatibacter riparius]
ATGCGCGCACAGATTCTGAAGTGGGGGAACAGCCTGGCGGTACGGATTCCTAAGCCGATTGCCGAGCAGGCGAGTTTGAG
CGAGGGTGATCCAATAGAGATCGAGGTCTCTGGGCAGGGCTCTCTGCAACTGCATCGCGGCGGGAAGATCCCGACCCTCG
CCCAACTGGTTGCGCAGATTACTCCAGAGAATCGCTATGAGGAGATCGGCACCGGTCCGGAGTTCGGCAAGGAAGCGGTG
GAGTGGTGA