Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4116409..4117028 Replicon chromosome
Accession NZ_CP070420
Organism Klebsiella quasipneumoniae strain B2663

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JT726_RS20035 Protein ID WP_002892050.1
Coordinates 4116810..4117028 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JT726_RS20030 Protein ID WP_002892066.1
Coordinates 4116409..4116783 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT726_RS20020 4111563..4112756 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JT726_RS20025 4112779..4115925 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit -
JT726_RS20030 4116409..4116783 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JT726_RS20035 4116810..4117028 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JT726_RS20040 4117187..4117753 + 567 WP_109546595.1 maltose O-acetyltransferase -
JT726_RS20045 4117725..4117856 - 132 WP_162543094.1 hypothetical protein -
JT726_RS20050 4117890..4118360 + 471 WP_023288642.1 YlaC family protein -
JT726_RS20055 4118329..4119786 - 1458 WP_109546596.1 PLP-dependent aminotransferase family protein -
JT726_RS20060 4119887..4120585 + 699 WP_109546597.1 GNAT family N-acetyltransferase -
JT726_RS20065 4120582..4120722 - 141 WP_072125433.1 type B 50S ribosomal protein L36 -
JT726_RS20070 4120722..4120985 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193963 WP_002892050.1 NZ_CP070420:4116810-4117028 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193963 NZ_CP093313:4824449-4824826 [Occallatibacter riparius]
GTGGACAGCACGGAAAAGCCGCTGTACTGGATCGGGAGCAGCAAGCGCGATCTAATGGAACTGCCCGTCCCCGTTCGAAA
GTTCTTCGGCCATGCGCTCCATTTCGCCCAGTTGGGCGAACAGCACGAGGCGGCAAAACCGTTGAAAGGATTCGGCGGCG
CGGGCGTACTTGAGATCGTTGAGGACAGCGTTGGCGGCACATATCGCGCGGTCTACACGGTGAAGTTCGCAGAAGCCGTC
TTCGTGTTGCACTGTTTTCAAAAGAAGAGTAAGAGCGGGATTGCGACGCCCAAGAAGGAATTGGATGTTATTTCTTCGCG
ACTGAAAGTCGCCGAAGCCGTTGCAAGGGAGATTCGTCATGCCAAAGCACGCCAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193963 WP_002892066.1 NZ_CP070420:4116409-4116783 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193963 NZ_CP093313:4824807-4825142 [Occallatibacter riparius]
ATGCCAAAGCACGCCAATAAGAACGCCGAGGTCGAGCGCAGCTCCGGCAATGTCTTTGCCGATCTTGCCCTGCATGATGC
CGAGCGGCTGAAGATCAAATCTGGTCTCGCGATCGAAATCACGCGGGCAGTGCGCCGCCTTGGCCTGACCCAGCAGGAAG
CGGCTGCGCGGATGGGCATCTCGCAGGCCAAGATATCCGGCCTGATGCGGGGGGATTTCAGCAACCTGTCGGAACACAAG
TTGATGGAATGTCTGAACCGCATTGGCTACAACATTGAGATCAAGGTGACTGCGGGGGAGCGGGTACCGGGTACCCGCAA
ACTCAAGGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References