Detailed information of TA system TA193961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2678007..2679595
• Replicon: chromosome
• Accession: NZ_CP070420
• Organism: Klebsiella quasipneumoniae strain B2663

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JT726_RS13105
• Protein ID: WP_044523012.1
• Coordinates: 2678007..2679329 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2N4W0X3
• Locus tag: JT726_RS13110
• Protein ID: WP_023289667.1
• Coordinates: 2679329..2679595 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT726_RS13090	2673063..2675564	+	2502	WP_109547356.1	fimbrial biogenesis outer membrane usher protein	-
JT726_RS13095	2675552..2676556	+	1005	WP_044523017.1	type 1 fimbrial protein	-
JT726_RS13100	2676698..2677990	+	1293	WP_044523014.1	glycoside hydrolase family 10 protein	-
JT726_RS13105	2678007..2679329	-	1323	WP_044523012.1	type II toxin-antitoxin system HipA family toxin	Toxin
JT726_RS13110	2679329..2679595	-	267	WP_023289667.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JT726_RS13115	2679861..2680187	-	327	WP_064154632.1	hydroxyisourate hydrolase	-
JT726_RS13120	2680184..2680684	-	501	WP_109547357.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JT726_RS13125	2680662..2682041	-	1380	WP_032452824.1	purine permease	-
JT726_RS13130	2682387..2683541	+	1155	WP_023289663.1	FAD-dependent urate hydroxylase HpxO	-
JT726_RS13135	2683522..2684445	-	924	WP_023289662.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49183.49 Da
• Isoelectric Point: 8.6110

>T193961 WP_044523012.1 NZ_CP070420:c2679329-2678007 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T193961 NZ_CP093313:3109549-3109827 [Occallatibacter riparius]
ATGATCCAGACGTTCGCGGATACCGAAACCGAGGCCCTCTTCCGAACGGGAAAAAGCCGGCAATGGAAGAACATCGCACG
AACGGCGGTGCGTCGGCTGCAAGCGCTTGACTTTGCGAGTGCGATGGAGGACTTGAAGAACCCTCCGGGAAATCGGCTCG
AACGGCTGAAAGGCGACCGGAAAGGTCAATGGAGCATTCGAATCAACGAGCAGTTCCGAATTTGCTTCCGGTGGGATGGC
AAGGACGCCTGGGATGTTGAGATCGTGGATTATCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9891.25 Da
• Isoelectric Point: 7.3163

>AT193961 WP_023289667.1 NZ_CP070420:c2679595-2679329 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT193961 NZ_CP093313:3109840-3110190 [Occallatibacter riparius]
ATGAGTATTCCCCGAAAGCCTGACGAGCGCAGCATCCCGGTTCATCCAGGGGAGTTTCTGCGTGAGGATTTTCTTACGCC
GCTGGGTTTGTCGGCCAATGCTTTGGCTCTTGCCTTGCGAGTGCCGGTTACGCGCATCTCTGAGATTGTGAGAGAACGCA
GAGGCATTACGGCAGATACGGCGCTACGGCTGGCGCGCTATTTCGGAACGACGCCGGATTTTTGGATGAAGATGCAGATG
GCATACGATCTCGCGGTTGCGAGCAGGGAGTCGAAGAAGCGGATCGAGGTCGAGATCTTTCCTGCGCCGCGTACGGAATC
CGGTGAATTGAAAGCCAGACAGATCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2N4W0X3