Detailed information of TA system TA193950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4792764..4793280
• Replicon: chromosome
• Accession: NZ_CP070415
• Organism: Klebsiella pneumoniae strain B1347

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JT725_RS23395
• Protein ID: WP_040216106.1
• Coordinates: 4792764..4793048 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JT725_RS23400
• Protein ID: WP_064162488.1
• Coordinates: 4793038..4793280 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT725_RS23370	4788181..4788489	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
JT725_RS23375	4788574..4788747	+	174	WP_032425422.1	hypothetical protein	-
JT725_RS23380	4788750..4789493	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
JT725_RS23385	4789850..4791988	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
JT725_RS23390	4792296..4792760	+	465	WP_064162487.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JT725_RS23395	4792764..4793048	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT725_RS23400	4793038..4793280	-	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JT725_RS23405	4793358..4795268	-	1911	WP_023325426.1	BglG family transcription antiterminator	-
JT725_RS23410	4795291..4796445	-	1155	WP_064162489.1	lactonase family protein	-
JT725_RS23415	4796512..4797252	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T193950 WP_040216106.1 NZ_CP070415:c4793048-4792764 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T193950 NZ_CP093298:1128547-1129293 [Bacillus amyloliquefaciens]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTCGCCCTTATTGATGCTTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACAGCTTCCTTG
TGCGACTATTCCGCACAAGCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT193950 WP_064162488.1 NZ_CP070415:c4793280-4793038 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT193950 NZ_CP093298:1129294-1129464 [Bacillus amyloliquefaciens]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA