Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4057032..4057651 Replicon chromosome
Accession NZ_CP070415
Organism Klebsiella pneumoniae strain B1347

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JT725_RS19910 Protein ID WP_002892050.1
Coordinates 4057433..4057651 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JT725_RS19905 Protein ID WP_002892066.1
Coordinates 4057032..4057406 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT725_RS19895 4052184..4053377 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JT725_RS19900 4053400..4056546 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JT725_RS19905 4057032..4057406 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JT725_RS19910 4057433..4057651 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JT725_RS19915 4057814..4058380 + 567 WP_002892030.1 maltose O-acetyltransferase -
JT725_RS19920 4058352..4058492 - 141 WP_004147370.1 hypothetical protein -
JT725_RS19925 4058513..4058983 + 471 WP_002892026.1 YlaC family protein -
JT725_RS19930 4058958..4060409 - 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
JT725_RS19935 4060510..4061208 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
JT725_RS19940 4061205..4061345 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JT725_RS19945 4061345..4061608 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T193948 WP_002892050.1 NZ_CP070415:4057433-4057651 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T193948 NZ_CP093291:2055864-2056214 [Bacillus mycoides]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGGGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT193948 WP_002892066.1 NZ_CP070415:4057032-4057406 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT193948 NZ_CP093291:2055572-2055859 [Bacillus mycoides]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References