Detailed information of TA system TA193937

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 790935..791592
• Replicon: chromosome
• Accession: NZ_CP070415
• Organism: Klebsiella pneumoniae strain B1347

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JT725_RS03925
• Protein ID: WP_040245400.1
• Coordinates: 791182..791592 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: JT725_RS03920
• Protein ID: WP_002916312.1
• Coordinates: 790935..791201 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT725_RS03895	786091..787524	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
JT725_RS03900	787643..788371	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
JT725_RS03905	788421..788732	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
JT725_RS03910	788896..789555	+	660	WP_048334397.1	hemolysin III family protein	-
JT725_RS03915	789706..790689	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
JT725_RS03920	790935..791201	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
JT725_RS03925	791182..791592	+	411	WP_040245400.1	protein YgfX	Toxin
JT725_RS03930	791599..792120	-	522	WP_002916308.1	flavodoxin FldB	-
JT725_RS03935	792221..793117	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
JT725_RS03940	793140..793853	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JT725_RS03945	793859..795592	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T193937 WP_040245400.1 NZ_CP070415:791182-791592 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T193937 NZ_CP093283:3833064-3833342 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT193937 WP_002916312.1 NZ_CP070415:790935-791201 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT193937 NZ_CP093283:3832801-3833061 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41