Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3080544..3081069 Replicon chromosome
Accession NZ_CP070379
Organism Streptomyces tsukubensis strain L20

Toxin (Protein)


Gene name relE Uniprot ID I2N5J6
Locus tag JVE63_RS11890 Protein ID WP_006346847.1
Coordinates 3080806..3081069 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G3UBC1
Locus tag JVE63_RS11885 Protein ID WP_030744248.1
Coordinates 3080544..3080813 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVE63_RS11865 3075649..3076401 - 753 WP_006346841.1 GntR family transcriptional regulator -
JVE63_RS11870 3076696..3078039 + 1344 WP_040914462.1 glycoside hydrolase family 18 protein -
JVE63_RS11875 3078418..3079863 - 1446 WP_130584856.1 DUF4190 domain-containing protein -
JVE63_RS11880 3080104..3080454 + 351 WP_006346845.1 DUF4326 domain-containing protein -
JVE63_RS11885 3080544..3080813 + 270 WP_030744248.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JVE63_RS11890 3080806..3081069 + 264 WP_006346847.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JVE63_RS11895 3081204..3082292 - 1089 WP_006346848.1 redox-regulated ATPase YchF -
JVE63_RS11900 3082672..3083271 + 600 WP_006346849.1 hypothetical protein -
JVE63_RS11905 3083317..3084072 - 756 WP_040914468.1 ROK family protein -
JVE63_RS11910 3084103..3085107 - 1005 WP_040914471.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10040.52 Da        Isoelectric Point: 7.1641

>T193918 WP_006346847.1 NZ_CP070379:3080806-3081069 [Streptomyces tsukubensis]
VSEYRTVFCPEAQAELRKIPRDMALRILAKLTELEADPLGFSTTALVSQPDRRRLRMGDYRVVYTIDNGELVVWFVHVGH
RSTVYDT

Download         Length: 264 bp

>T193918 NZ_CP093281:c837280-836900 [Pseudomonas sp. T1-3-2]
ATGGCAATTTATGTTTTAAAACCATTCGACAGAAATACCAAAGCTGATGGGATTGACGACGGCAAGCTATGCATTGCAGC
GTTAGAAGTTATCGCGGGTCGATATGAAGCTAATTTAGGCGGGGTATATAAGAAACGCATTCCCTTAACCAAAGGTAAAA
GTAGTGGTGCCAGAGCTGTCATTGCTTTCAAAATTGATAAGCACCTCTTCTTTGTAAATGGGTATGCAAAGTCAGCAGTC
AAAAGCACAATACGAGAAATGACCGAAACTGAACTGCTACTTTATAAGCAAGTTGCCAAAGAGTTATTCAATCTCACCAC
TGAACAAGCAAGACGAGCGATTAGGGCGGGGAAAATGCGAGAGGTGCAGTGTGATGGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10258.73 Da        Isoelectric Point: 4.7473

>AT193918 WP_030744248.1 NZ_CP070379:3080544-3080813 [Streptomyces tsukubensis]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT193918 NZ_CP093281:c836907-836581 [Pseudomonas sp. T1-3-2]
ATGGTTAATTACCTTAAGGATCTTCAGGAAATCGCACATGATTTCAATGAAATTGGCGTCATCTCAGATGATCTTAAAGA
AAAAATTGACTCCAGGGTAAGATTGCGCGAGTTGCGAGCGACACTGCCTGTTCTGCCTATGATGTCGGGCCAGGCTATTA
GAGAATTGCGTGAGCGCTTGGGCTTAAGTCAAGCAATGCTGGCGGCTTGCGTTGGAATGTCAGTCGCAACGGTAATCAAA
TGGGAACGTGAAGAGAAAAAACCTAACGGCGCGGCGCTGCGTTTGCTCAATATTATTGATCGTAAAGGTTTGAGTGTTCT
TCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2N5J6

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3UBC1

References