Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 7570756..7571393 Replicon chromosome
Accession NZ_CP070373
Organism Streptomyces sp. MBT27

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GWQ54_RS33430 Protein ID WP_167152962.1
Coordinates 7570977..7571393 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GWQ54_RS33425 Protein ID WP_167152963.1
Coordinates 7570756..7570974 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ54_RS33405 7565988..7568447 - 2460 WP_193587890.1 UvrD-helicase domain-containing protein -
GWQ54_RS33410 7568535..7569296 - 762 WP_167152965.1 zf-HC2 domain-containing protein -
GWQ54_RS33415 7569293..7569880 - 588 WP_161245204.1 sigma-70 family RNA polymerase sigma factor -
GWQ54_RS33420 7570030..7570590 - 561 WP_167152964.1 ABATE domain-containing protein -
GWQ54_RS33425 7570756..7570974 + 219 WP_167152963.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GWQ54_RS33430 7570977..7571393 + 417 WP_167152962.1 PIN domain nuclease Toxin
GWQ54_RS33435 7571402..7572556 - 1155 WP_167152961.1 uroporphyrinogen-III synthase -
GWQ54_RS33440 7572659..7574005 - 1347 WP_167152960.1 MFS transporter -
GWQ54_RS33445 7574146..7575303 - 1158 WP_167152959.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15556.39 Da        Isoelectric Point: 6.2108

>T193917 WP_167152962.1 NZ_CP070373:7570977-7571393 [Streptomyces sp. MBT27]
MLRYLIDSTAVWRLQRSPALSEAWGHETDEGSIGSCHPQRTEFRRSARNLDEYDAMTAMFGDLYPDAPVPKAAWSWIETA
QYRLAARGRHQSLSVVDWLLCATAAHHGLVVLHDDKDFAAAADLLPDIREHNVNHAPH

Download         Length: 417 bp

>T193917 NZ_CP093280:c6616471-6616289 [Pseudomonas sp. T1-3-2]
ATGCGCAGTCGCGAAATGATCAGATTGATCATGCAAGACGGTTGGTTCCTCGTGGCTGTCAATGGCAGTCATCACCAATA
CAAACACCCGCGTAAATCAGGAAGGGTGACTATCAAGCATCCGGATGGAGATCTGCCGAAAGGAACGATCAACAGCATCC
TTAAGCAGGCGGGCTTGAAATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8422.38 Da        Isoelectric Point: 7.2051

>AT193917 WP_167152963.1 NZ_CP070373:7570756-7570974 [Streptomyces sp. MBT27]
MSATQIDIDDEALAEAMRLSGSRTKKETVNLALREYSERRRRTEARLRHFKLAQDWDDESFWRLHAAEKGAS

Download         Length: 219 bp

>AT193917 NZ_CP093280:c6616257-6615856 [Pseudomonas sp. T1-3-2]
ATGAAATTTGCGGTCGTTCTACATAAGGATGAAGACTCGGAATACGGCGTGATCGTCCCGGACGTTCCCGGGTGTTTCTC
GGCGGGTACTACGGTCACCGAGGCACTTGAGAGTGTCGAACAGGCGCTGGCCTTTCACTTTGAGGGCCTGGTTGTGGACG
GCGAGGTGCTGCCCAACCCCAAATGCATAGATGAGCATATGAATAATCCGGATTATGCGGGTGGGGTCTGGGCGGTGGTT
GAAATCGATATCACGCCGTATTTTGGTAAGTCGGTGCGGTTTAACGCGACATTGCCAGAGCATCTGCTGGATCGCATCGA
CCAGACGGTCAGCCGCGACCGTCGTTATAAATCGCGTTCGGGGTTCCTGGCCGCGGCGGCATTGCGCGAGCTTTCTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References