Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 572326..572888 Replicon chromosome
Accession NZ_CP070371
Organism Paracoccus sp. H4-D09

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JWJ88_RS16025 Protein ID WP_205296692.1
Coordinates 572326..572697 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JWJ88_RS16030 Protein ID WP_205296693.1
Coordinates 572697..572888 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWJ88_RS16005 568533..569102 - 570 WP_205296690.1 phage tail length tape measure family protein -
JWJ88_RS16010 569410..569990 + 581 Protein_570 hypothetical protein -
JWJ88_RS16015 570235..571973 + 1739 Protein_571 DUF3363 domain-containing protein -
JWJ88_RS16020 571980..572309 - 330 WP_205296691.1 hypothetical protein -
JWJ88_RS16025 572326..572697 - 372 WP_205296692.1 type II toxin-antitoxin system VapC family toxin Toxin
JWJ88_RS16030 572697..572888 - 192 WP_205296693.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JWJ88_RS16035 573094..573511 + 418 Protein_575 conjugal transfer protein TraG -
JWJ88_RS16045 574843..575412 + 570 WP_205296695.1 hypothetical protein -
JWJ88_RS16050 575899..576625 + 727 Protein_578 TrbI/VirB10 family protein -
JWJ88_RS16055 576614..576967 - 354 Protein_579 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 517077..573055 55978
- flank IS/Tn - - 573550..574347 797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 12989.26 Da        Isoelectric Point: 6.9887

>T193915 WP_205296692.1 NZ_CP070371:c572697-572326 [Paracoccus sp. H4-D09]
VILVDTSIWIDHLRAGDAELAGLLKAGLVLAHPFVIGELALGSLKDREAVIAAMQGLPRTSVASHAEVMALIEARQLFSL
GIGYVDAHLIAATLLAPGTTLWTRDRRLSAAAARVGILHVLPQ

Download         Length: 372 bp

>T193915 NZ_CP093280:2134013-2134219 [Pseudomonas sp. T1-3-2]
ATGTCTAAACAAGAGAAGCTTCTGGCCAAACTGCTCAATAAGCAGGGTAGTTTTACCTGGCAGGAGCTTGTCACGCTCCT
GCGAGGGCTAGGGTACGATCAGGTGGAGGGGGTGGGCAGTCGCGTGAAGTTTGATAACGGCAATCCCATGGCCATGATCA
ACCTGCATAAGCCGCACCCTGGCAATGAGTTGAAGGCTTACCTCTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6932.03 Da        Isoelectric Point: 10.9487

>AT193915 WP_205296693.1 NZ_CP070371:c572888-572697 [Paracoccus sp. H4-D09]
MRTTLNLDDELLRQAHDLTGIGEKAVLVREGLKALIERESARRLALLGGTDKRAAVAPRRQPA

Download         Length: 192 bp

>AT193915 NZ_CP093280:2134261-2134602 [Pseudomonas sp. T1-3-2]
ATGAGCAAACTGCTTCAACATCGTGGTTACTTCGGTTCCATCGAGGCAAGTCCTGAAGACAATTGTCTATTCGGCAAGCT
CCAGTTCATTCGGGCGCTGGTCAGTTATGAAGGGGAGACAGTTGCAGAGCTCAGCCAGGCTTTCCGTGACGCTGTTGATG
ATTATCTTGCGACCTGTGACTCCCTGAATCAAAACCCTGAAATTCCCTGCAAGGGATCCTTCAATGTCCGGGTGGGCCAC
GATCTTCACTTGGCGGCTACTGTAGCGGCGCTCAAGCAGAGCATCTCCTTGAACGACCTGACCCGTCAGGCCTTGAGGGA
GTACTTGGGCAACCATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References