Detailed information of TA system TA193914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 2746561..2746985
• Replicon: chromosome
• Accession: NZ_CP070367
• Organism: Sphingomonas paucimobilis strain ZJSH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0C9M624
• Locus tag: JT366_RS13195
• Protein ID: WP_007406919.1
• Coordinates: 2746561..2746836 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JT366_RS13200
• Protein ID: WP_197913076.1
• Coordinates: 2746824..2746985 (-)
• Length: 54 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT366_RS13175	2742134..2742586	+	453	WP_007406920.1	large conductance mechanosensitive channel protein MscL	-
JT366_RS13180	2742741..2743172	-	432	WP_007406932.1	Rrf2 family transcriptional regulator	-
JT366_RS13190	2743963..2746533	-	2571	WP_007406927.1	DNA mismatch repair protein MutS	-
JT366_RS13195	2746561..2746836	-	276	WP_007406919.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT366_RS13200	2746824..2746985	-	162	WP_197913076.1	antitoxin	Antitoxin
JT366_RS13205	2747136..2749394	+	2259	WP_007406925.1	NADP-dependent malic enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10372.73 Da
• Isoelectric Point: 5.5940

>T193914 WP_007406919.1 NZ_CP070367:c2746836-2746561 [Sphingomonas paucimobilis]
MAQISWSVQASLQLAAIVDYIEQFDPDAARRLGDRLIDVAESLRQFPDRGRPISHGRREMVTVRPYVLRYEHDGETVLIL
GIRHAAQLSDD

Nucleotide

• Length: 276 bp

>T193914 NZ_CP093280:1935428-1936003 [Pseudomonas sp. T1-3-2]
ATGAGGCATTCACCGTTCACTGTTATCTATGATGCTTGTGTGCTGTATCCAGCTCCTCTGCGTGATCTGCTAATGCATTT
GGCCTTGACCGGCGTCTATCGTGCGCGCTGGTCCGGGCAGATCCATGATGAGTGGACGCGAAATGTGCTGAAAAATCGTT
CCGACCTGACGAAAGCCCAGCTTCATCGTACTGTCGAGGCCATGAACCGGGCAGTTCCTGATTGTCTTGTGAGCGACTAC
GAGCCGTTGATGCCAGGGCTTGACCTTCCTGACGAAGATGATCGGCATGTGTTGGCCGCTGCAATCAAATGCGGCGCAAC
GGTCATCGTCACATACAATCTGAAGGATTTCCCCGCTGAGATCTTGAAGCGCTTTGAGATCGAGGCTTTGCACCCCGATG
TCTTTCTTTCTGACGTCTGGGACCTGGATCAAGCAGCCGTACTCGAGGCAGTTCAAAAGCAGCGCGCTTCGTTGAAGAAT
CCTAGGTACACGGCTCGCGAGCTACTGGATACTCTGCTTACGCAACGGCTCCCAGAAATCGTCAAGCACCTCTCCAGCTA
CGAGTTGTTCATTTGA

Antitoxin

Protein

• Length: 54 a.a.
• Molecular weight: 6226.04 Da
• Isoelectric Point: 5.8087

>AT193914 WP_197913076.1 NZ_CP070367:c2746985-2746824 [Sphingomonas paucimobilis]
IFEQRDEAAELAADERARADFKAGRFVSHEKMAEWLKTWGTPDRKPLPPEWLK

Nucleotide

• Length: 162 bp

>AT193914 NZ_CP093280:1934964-1935428 [Pseudomonas sp. T1-3-2]
ATGACTACCGCCGATCTGGCTCGAAGCGTCCTTCCAGATGAGAGAGCGATCGCCGCGGCTACTGAATCAAGCCGCCAGAT
TGCTGCTTTCGTTTCGACGAAGCTGGATACTCAGCGCATTGAACTGATTGATGAAGCCCAGCAACGCCAAGCCGTTGAGC
TACCAACGTTTGCTCTTAGATTGCTCGGGGAAATATTGAGCGAACTGGCCTTGGGCAACACCGTAAAGGTGGTGCCGATC
CACGCAGAACTGACGACTCAAGAAGGCGCCGACATGCTCAACGTCTCACGCCCACATCTTGTCAAGCTGCTGGACGACGG
TCAGATTCCACACACGAAGACCGGCAGCCACCGCCGCATCAAGTTCACCGATATCATGGCCTACAAAGCCGACCGTGACA
GAGCGAGCCAAGCCGCGATGGAAGAGCTGGCTGCACAAGCCCAAGAGCTTAATATGGGGTATTAA

Structures

Toxin

• AlphaFold DB: A0A0C9M624