Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3979353..3980006 Replicon chromosome
Accession NZ_CP070358
Organism Acinetobacter baumannii strain AB5075-VUB-itrA::ISAba13

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag JWB57_RS19460 Protein ID WP_000931890.1
Coordinates 3979617..3980006 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag JWB57_RS19455 Protein ID WP_001288210.1
Coordinates 3979353..3979610 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWB57_RS19435 (JWB57_02040) 3974869..3975876 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
JWB57_RS19440 (JWB57_02045) 3975895..3976272 + 378 WP_001216380.1 50S ribosomal protein L17 -
JWB57_RS19445 (JWB57_02050) 3976453..3977943 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
JWB57_RS19450 (JWB57_02055) 3977993..3979165 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
JWB57_RS19455 (JWB57_02060) 3979353..3979610 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
JWB57_RS19460 (JWB57_02065) 3979617..3980006 + 390 WP_000931890.1 membrane protein Toxin
JWB57_RS19465 (JWB57_02070) 3980776..3981861 + 1086 WP_000049106.1 hypothetical protein -
JWB57_RS19470 (JWB57_02075) 3981939..3982505 + 567 WP_000651536.1 rhombosortase -
JWB57_RS19475 (JWB57_02080) 3982693..3984888 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T193909 WP_000931890.1 NZ_CP070358:3979617-3980006 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T193909 NZ_CP093277:158549-159031 [Raoultella sp. HC6]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT193909 WP_001288210.1 NZ_CP070358:3979353-3979610 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT193909 NZ_CP093277:158295-158561 [Raoultella sp. HC6]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAATCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References