Detailed information of TA system TA193908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 6299779..6300326
• Replicon: chromosome
• Accession: NZ_CP070356
• Organism: Pseudomonas sp. PDNC002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JVX91_RS28545
• Protein ID: WP_205337373.1
• Coordinates: 6300039..6300326 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F0DTW6
• Locus tag: JVX91_RS28540
• Protein ID: WP_024762620.1
• Coordinates: 6299779..6300048 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVX91_RS28520	6295691..6297130	-	1440	WP_205337369.1	succinate-semialdehyde dehydrogenase	-
JVX91_RS28525	6297127..6298161	-	1035	WP_205337370.1	aldo/keto reductase	-
JVX91_RS28530	6298172..6298684	-	513	WP_205337371.1	formaldehyde-activating enzyme	-
JVX91_RS28535	6299013..6299591	-	579	WP_205337372.1	DUF2846 domain-containing protein	-
JVX91_RS28540	6299779..6300048	+	270	WP_024762620.1	ribbon-helix-helix protein, CopG family	Antitoxin
JVX91_RS28545	6300039..6300326	+	288	WP_205337373.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JVX91_RS28550	6300334..6300927	-	594	WP_205337374.1	GNAT family acetyltransferase	-
JVX91_RS28555	6301038..6302330	-	1293	WP_205337375.1	acyltransferase family protein	-
JVX91_RS28560	6302363..6303520	-	1158	WP_205337376.1	phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein	-
JVX91_RS28565	6303517..6304092	-	576	WP_205337377.1	YceI family protein	-
JVX91_RS28570	6304195..6305100	-	906	WP_205340128.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-93)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10925.54 Da
• Isoelectric Point: 8.4752

>T193908 WP_205337373.1 NZ_CP070356:6300039-6300326 [Pseudomonas sp. PDNC002]
MRVIYAPAALRDLDRLRRFLRETNPTAARRAGQIILQATQALGAYPQMGRLIDDLPIEFREWPIDFGDSGYLARYHIDGE
TLVILAIRHQREAGY

Nucleotide

• Length: 288 bp

>T193908 NZ_CP093276:c5249148-5248861 [Raoultella sp. HC6]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGGTTCGAGGAGGCGGT
ACTGGTTTTTGACGATCCGCGGCATCTTTCCCGCCAGGATCGTTATGAAAACGGTGAGCATCGATGGCAAACCATCGGCC
TCGCTCATGGAATTATCGTTATTCTTGTGGTGCATTCGGTCCGCTTTGAAAGCGGGGCTGAGGTGATTCGTATCATCAGC
GCCCGGAAGGCGGACGGCAAAGAGAGGAGTCGTTATGAGCACAGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10472.62 Da
• Isoelectric Point: 4.4422

>AT193908 WP_024762620.1 NZ_CP070356:6299779-6300048 [Pseudomonas sp. PDNC002]
MATSVKLDEEMLARVRELAELRQRSPHWIMREAIGQYVVREEQREKLKRDTEQAWEEFQATGQHVTAEAVESWLNSWGDE
DEQAAPKCE

Nucleotide

• Length: 270 bp

>AT193908 NZ_CP093276:c5248874-5248572 [Raoultella sp. HC6]
ATGAGCACAGTTAAATACAAGCGCGGCAATCCGGCCGGGCTTAGCGCTCAGCGTGAAGACGAGCTCAGAGCGCTGGCGAA
CAAAGCGGATGGCGAAATTGATTACAGCGATATCCCCGCTTCAGGTGATGAACGGTGGCCGGACGCGGTGCGCGGTAAAT
TCTACCGACCGTTGAAAACCCAGGCCTCTGTCCGCATCGACGCTGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAAACCCGGCTGAATGCGATTTTAAGAGAAGCGATGAACCGCGATCTGGGTGAGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0F0DTW6