Detailed information of TA system TA193905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 540698..541245
• Replicon: plasmid unnamed_2
• Accession: NZ_CP070354
• Organism: Ensifer sp. PDNC004

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JVX98_RS30810
• Protein ID: WP_192448467.1
• Coordinates: 540952..541245 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JVX98_RS30805
• Protein ID: WP_205239629.1
• Coordinates: 540698..540952 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVX98_RS30795	536236..538929	+	2694	WP_205239627.1	TonB-dependent receptor	-
JVX98_RS30800	538985..540469	-	1485	WP_205239628.1	MFS transporter	-
JVX98_RS30805	540698..540952	+	255	WP_205239629.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JVX98_RS30810	540952..541245	+	294	WP_192448467.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JVX98_RS30815	541332..542771	-	1440	WP_205239630.1	aldehyde dehydrogenase family protein	-
JVX98_RS30820	542996..543934	-	939	WP_205239631.1	LysR family transcriptional regulator	-
JVX98_RS30825	544030..544278	+	249	WP_205239632.1	hypothetical protein	-
JVX98_RS30830	544287..544793	+	507	WP_205239633.1	SgcJ/EcaC family oxidoreductase	-
JVX98_RS30835	544786..545259	+	474	WP_205239634.1	SRPBCC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..833710	833710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11037.71 Da
• Isoelectric Point: 6.6435

>T193905 WP_192448467.1 NZ_CP070354:540952-541245 [Ensifer sp. PDNC004]
MAFRLSVAAEEDIIAIAADGVRLFGSPQARRYHDELFDLFALIAANPRMARERTELSPPMRIHPFKAHLVVYRIDADGDI
LVVRVRHGHEDWMSNAL

Nucleotide

• Length: 294 bp

>T193905 NZ_CP093276:3058637-3059098 [Raoultella sp. HC6]
GTGATCCTCTACCGCCTGACTAAAACCCGCTTTCTGACGACCGCCTGGTCTGGTTTTGGCGCGAAAGAGGCCGGCGGCCG
CTGGAACAGCGTTGGCACGGCGATGGTCTATTTGTCGGAAGCCGCCTCTCTGACCATGCTGGAAACGCTGGTGCACATCA
ATGCTCCGCAGCTGCTGGATGATTTCACGCTGCTGAGCATTGACGTACCGGACGACCAGGTGCTGACCGTCGATCCGCAC
TCACTTCCCGCGGACTGGGCCCGCGAGGATGCGCCAGCCCGGCTGGCGCGCTACGGTGACGAGTGGGCCGCGAGCGCGGC
ATCAGCGGCATTACGCGTACCGAGCGCCCTGTCGCCGGTGGAGTATAACTATCTATTCAATCCTCAACACCCTGCCGTTT
TCGATCTGCTGGCAAGCGTAAAAAGGATCCCCTTCCGCTTTGATACTCGTCTTAAGGCGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9415.54 Da
• Isoelectric Point: 9.7734

>AT193905 WP_205239629.1 NZ_CP070354:540698-540952 [Ensifer sp. PDNC004]
MATMNVSLPDPMKEWVEAQARTGRYANASDYVRDLIRRDQERNDKVAAMQRFVDDGLNSGVGSRSKDALFSAALARAEAP
RDRK

Nucleotide

• Length: 255 bp

>AT193905 NZ_CP093276:3058197-3058640 [Raoultella sp. HC6]
ATGAAAGTCTATTCCCCGACCGAGAGCGCAGAAAAAAATCTCAGCCCCTGGCACGCCATCGGCCTCGACGCCGAGGACGG
CATTGCGCTGATGGGTAAAATTAGCCACGGGCTGGAAGGTTCCGTCGCCCGGCAAATTTCCGCGTGGGCGGAGATCACCC
CTGCCGAACTGCGCAAAATGTCAGGTATTGCGAATACCACCTTTAACCGCAGCATTAAATCGCGCTTTTCCGCCGACCAA
AGCGAGCGCCTGGTGCGCATTCTTCGCGTTATCGAGCGGGCGGTGGAGCTGTTCGAAGGCGATAAAGAGGCGGCGCAGAA
GTGGATGAATGAACCCAACCGCGCGCTCGGCTGGAAAACGCCGGCCGAGGTGGTCTCTTCTGAAACCGGCGCGCTGGAGG
TGATGCGCCTGATCACGCGCGTGGAGCACGGGGTTTATTCGTGA