Detailed information of TA system TA193903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 589766..590646
• Replicon: plasmid unnamed_1
• Accession: NZ_CP070352
• Organism: Ensifer sp. PDNC004

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JVX98_RS02645
• Protein ID: WP_192449534.1
• Coordinates: 589766..590275 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JVX98_RS02650
• Protein ID: WP_192449533.1
• Coordinates: 590275..590646 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVX98_RS02625	585248..586114	+	867	WP_205236765.1	sulfate ABC transporter permease subunit CysT	-
JVX98_RS02630	586104..587027	+	924	WP_192449536.1	sulfate ABC transporter permease subunit CysW	-
JVX98_RS02635	587050..588090	+	1041	Protein_526	sulfate/molybdate ABC transporter ATP-binding protein	-
JVX98_RS02640	588348..589712	+	1365	WP_205236766.1	FAD-binding protein	-
JVX98_RS02645	589766..590275	-	510	WP_192449534.1	RES domain-containing protein	Toxin
JVX98_RS02650	590275..590646	-	372	WP_192449533.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
JVX98_RS02655	590718..591503	-	786	WP_192449532.1	crotonase/enoyl-CoA hydratase family protein	-
JVX98_RS02660	591500..592369	-	870	WP_205236767.1	hydroxymethylglutaryl-CoA lyase	-
JVX98_RS02665	592366..594354	-	1989	WP_205236768.1	acetyl-CoA carboxylase biotin carboxylase subunit	-
JVX98_RS02670	594370..594753	-	384	WP_205236769.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katA	1..1791989	1791989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (8-162)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18760.18 Da
• Isoelectric Point: 5.6294

>T193903 WP_192449534.1 NZ_CP070352:c590275-589766 [Ensifer sp. PDNC004]
MAIGEPVRLWRAYVPRWAHAPLSGEGAGRYGGRWNPVGTPTIYAARELSTAWAEYNQGFVQHPALIAQLELRFSRLADLT
APEILSDLGLSEDIHQSEWRDALDRGLVPETHRLQQALSDRGFDGLIYPSFMSPGGTCVALWRWNAGEGAELKVIDPDGR
LPKNPASWL

Nucleotide

• Length: 510 bp

>T193903 NZ_CP093276:919556-919966 [Raoultella sp. HC6]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGTTCGCAGTGGTTCTCGCTGTTGCTCCACGGCGTCGTGGCGGC
CATCGTCCTGCTGATGCCCTGGCCGCTCAGCTACACCCCGTTATGGCTACTGCTGCTCTCTCTGGTGGTGTTTGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATAAAGCTGCTGACCGATTCCCGACTGCGCTGGCAAAAAGCG
GAGTGGGAGATCGTCGGCATGCCGTGGGTCATTAACAGCGGGATGCTGCTGCGTCTGCGCCATACGCAAACGCGTCGCAG
CCAGCACCTGTGGGTGGCGGCTGATAGCATGGATGCGAAGGAGTGGCGCGATTTGCGTCGGCTGGTGCTGAACAAACCGG
CGCAGGACTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 12953.97 Da
• Isoelectric Point: 9.8060

>AT193903 WP_192449533.1 NZ_CP070352:c590646-590275 [Ensifer sp. PDNC004]
MAAVGLNISTAHYGENHSSFLSARLVAERLGVTLAELAKLIGVARNTLTAKSSARKVDAALSGIVRILAMAGEMAGDDSR
AVIWFKHQPIPGWAGKTAYDLVGEGKVDKVLAYLEAVRSGVYA

Nucleotide

• Length: 372 bp

>AT193903 NZ_CP093276:919309-919575 [Raoultella sp. HC6]
ATGGACATTACTAACAAAGCCCGCATCCACTGGGCATGCCGCCGGGGTATGCGTGAACTCGACATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAGCAGCTGTTCATCCGGTTGTTAGAAAACGACGACCCGGATC
TGTTCAACTGGTTGATGAACCACGGCGAACCCTCCGACGCGCAGCTGCAGCGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA