Detailed information of TA system TA193902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 5792421..5793438
• Replicon: chromosome
• Accession: NZ_CP070348
• Organism: Mycolicibacterium boenickei strain PDNC014

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JVX93_RS28065
• Protein ID: WP_090434634.1
• Coordinates: 5792848..5793438 (+)
• Length: 197 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: JVX93_RS28060
• Protein ID: WP_090434631.1
• Coordinates: 5792421..5792810 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVX93_RS28040	5788438..5789001	-	564	WP_124714004.1	GNAT family N-acetyltransferase	-
JVX93_RS28045	5789035..5789445	-	411	WP_205263732.1	transglycosylase family protein	-
JVX93_RS28050	5789843..5791198	-	1356	WP_090434628.1	LysM peptidoglycan-binding domain-containing protein	-
JVX93_RS28055	5791338..5792351	+	1014	WP_205266390.1	TIGR03617 family F420-dependent LLM class oxidoreductase	-
JVX93_RS28060	5792421..5792810	+	390	WP_090434631.1	hypothetical protein	Antitoxin
JVX93_RS28065	5792848..5793438	+	591	WP_090434634.1	zeta toxin family protein	Toxin
JVX93_RS28070	5793446..5793802	-	357	WP_090434637.1	thiocyanate hydrolase	-
JVX93_RS28075	5793813..5794538	-	726	WP_205263733.1	thiocyanate hydrolase subunit gamma	-
JVX93_RS28080	5794572..5795396	-	825	WP_090434642.1	nitrile hydratase subunit beta	-
JVX93_RS28085	5795663..5796301	+	639	WP_164481095.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
JVX93_RS28090	5796350..5796955	+	606	WP_205263734.1	methyltransferase domain-containing protein	-
JVX93_RS28095	5796952..5797746	-	795	WP_205266391.1	thioesterase family protein	-
JVX93_RS28100	5798011..5798427	+	417	WP_090434648.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 197 a.a.
• Molecular weight: 21399.44 Da
• Isoelectric Point: 6.7682

>T193902 WP_090434634.1 NZ_CP070348:5792848-5793438 [Mycolicibacterium boenickei]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKRRWPEDPAPHSYEAALVAAETRAKLIELGESFIAETVFSH
PSKLELIDEAHAAGYTVILHCILIPEDLAVLRVHHRVQAGGHHVPEAKIRERYQRLWDLVAIAAMRVDSATFYDNSTIRG
PRIVAQIAGGFVVGSPSWPKWTPAALNSRSVEGSDH

Nucleotide

• Length: 591 bp

>T193902 NZ_CP093276:c759341-758964 [Raoultella sp. HC6]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13709.12 Da
• Isoelectric Point: 4.9497

>AT193902 WP_090434631.1 NZ_CP070348:5792421-5792810 [Mycolicibacterium boenickei]
MTDTADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIPLRELTAEEGAVFDAEI
AASIEESLARADYGKTLAARGITTVALDENGDIVQYRPDGSTAALAQQQ

Nucleotide

• Length: 390 bp

>AT193902 NZ_CP093276:c759717-759391 [Raoultella sp. HC6]
ATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTTTGGCGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACGCGGATTTACGCCATCTCGACCAGGCATTCCCGC
TACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGTCTATCTCGCAATTTACCCGACACCTGCAACAAC
AGAATAA