Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 730297..730929 Replicon chromosome
Accession NZ_CP070348
Organism Mycolicibacterium boenickei strain PDNC014

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag JVX93_RS03620 Protein ID WP_205264629.1
Coordinates 730297..730746 (-) Length 150 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag JVX93_RS03625 Protein ID WP_205264630.1
Coordinates 730750..730929 (-) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVX93_RS03595 726695..726937 + 243 WP_090428755.1 hypothetical protein -
JVX93_RS03600 726947..728689 + 1743 WP_090427037.1 fumarate reductase (quinol) flavoprotein subunit -
JVX93_RS03605 728691..729434 + 744 WP_205264626.1 succinate dehydrogenase/fumarate reductase iron-sulfur subunit -
JVX93_RS03610 729431..729805 + 375 WP_205264627.1 fumarate reductase subunit C -
JVX93_RS03615 729867..730226 + 360 WP_205264628.1 fumarate reductase subunit FrdD -
JVX93_RS03620 730297..730746 - 450 WP_205264629.1 SRPBCC family protein Toxin
JVX93_RS03625 730750..730929 - 180 WP_205264630.1 antitoxin Antitoxin
JVX93_RS03630 731000..733375 - 2376 WP_205264631.1 HAD-IC family P-type ATPase -
JVX93_RS03635 733436..734542 - 1107 WP_205264632.1 MBL fold metallo-hydrolase -
JVX93_RS03640 734544..735278 - 735 WP_090427018.1 enoyl-CoA hydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-145)

Antitoxin

(4-52)


Sequences


Toxin        


Download         Length: 150 a.a.        Molecular weight: 16099.72 Da        Isoelectric Point: 9.6754

>T193901 WP_205264629.1 NZ_CP070348:c730746-730297 [Mycolicibacterium boenickei]
MAKLSVSVDVPLPPEKAWEYASDLSRYDEWLSIHRAWRSMLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPHSLTLN
GDGRGGVKVKLIGKIAPAAVDGVDGAKVTFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKSLYASS

Download         Length: 450 bp

>T193901 NZ_CP093272:c39489-39007 [Klebsiella oxytoca]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6392.07 Da        Isoelectric Point: 4.4883

>AT193901 WP_205264630.1 NZ_CP070348:c730929-730750 [Mycolicibacterium boenickei]
MGFLDKAKDLLSQNADKVEQAIDKAGDVIDEKTQGKYSGAVDKAQEAAKNAINKEEPQQ

Download         Length: 180 bp

>AT193901 NZ_CP093272:c39743-39477 [Klebsiella oxytoca]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References