Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2313333..2313969 Replicon chromosome
Accession NZ_CP070345
Organism Bacillus sp. PDNC022

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag JVX94_RS12035 Protein ID WP_024425388.1
Coordinates 2313333..2313683 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag JVX94_RS12040 Protein ID WP_003214273.1
Coordinates 2313688..2313969 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVX94_RS11995 2308363..2308962 - 600 WP_205183263.1 SpoIIE family protein phosphatase -
JVX94_RS12000 2308962..2309750 - 789 WP_024427378.1 RNA polymerase sigma factor SigB -
JVX94_RS12005 2309716..2310204 - 489 WP_048240335.1 anti-sigma B factor RsbW -
JVX94_RS12010 2310201..2310530 - 330 WP_017358393.1 anti-sigma factor antagonist -
JVX94_RS12015 2310590..2311597 - 1008 WP_095407804.1 PP2C family protein-serine/threonine phosphatase -
JVX94_RS12020 2311608..2312009 - 402 WP_024427376.1 anti-sigma regulatory factor -
JVX94_RS12025 2312012..2312380 - 369 WP_003214235.1 RsbT antagonist protein RsbS -
JVX94_RS12030 2312385..2313215 - 831 WP_024427375.1 RsbT co-antagonist protein RsbRA -
JVX94_RS12035 2313333..2313683 - 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JVX94_RS12040 2313688..2313969 - 282 WP_003214273.1 hypothetical protein Antitoxin
JVX94_RS12045 2314263..2315429 - 1167 WP_095407803.1 alanine racemase -
JVX94_RS12050 2315569..2316585 - 1017 WP_095407802.1 outer membrane lipoprotein carrier protein LolA -
JVX94_RS12055 2316746..2317111 - 366 WP_205183266.1 holo-ACP synthase -
JVX94_RS12060 2317206..2317811 + 606 WP_205183270.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T193900 WP_024425388.1 NZ_CP070345:c2313683-2313333 [Bacillus sp. PDNC022]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T193900 NZ_CP093271:c4711974-4711717 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT193900 WP_003214273.1 NZ_CP070345:c2313969-2313688 [Bacillus sp. PDNC022]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT193900 NZ_CP093271:c4711706-4711155 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGACCTGGTTGCCGATTTGCTCAACGATGAAAGTGCTCACCCGAGATTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References