Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2313333..2313969 Replicon chromosome
Accession NZ_CP070345
Organism Bacillus sp. PDNC022

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag JVX94_RS12035 Protein ID WP_024425388.1
Coordinates 2313333..2313683 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag JVX94_RS12040 Protein ID WP_003214273.1
Coordinates 2313688..2313969 (-) Length 94 a.a.

Genomic Context

JVX94_RS12060JVX94_RS11995JVX94_RS12000JVX94_RS12005JVX94_RS12010JVX94_RS12015JVX94_RS12020JVX94_RS12025JVX94_RS12030JVX94_RS12035JVX94_RS12040JVX94_RS12045JVX94_RS12050JVX94_RS12055
Location: 2317206..2317811 (606 bp)
Type: Others
Protein ID: WP_205183270.1
Location: 2308363..2308962 (600 bp)
Type: Others
Protein ID: WP_205183263.1
Location: 2308962..2309750 (789 bp)
Type: Others
Protein ID: WP_024427378.1
Location: 2309716..2310204 (489 bp)
Type: Others
Protein ID: WP_048240335.1
Location: 2310201..2310530 (330 bp)
Type: Others
Protein ID: WP_017358393.1
Location: 2310590..2311597 (1008 bp)
Type: Others
Protein ID: WP_095407804.1
Location: 2311608..2312009 (402 bp)
Type: Others
Protein ID: WP_024427376.1
Location: 2312012..2312380 (369 bp)
Type: Others
Protein ID: WP_003214235.1
Location: 2312385..2313215 (831 bp)
Type: Others
Protein ID: WP_024427375.1
Location: 2313333..2313683 (351 bp)
Type: Toxin
Protein ID: WP_024425388.1
Location: 2313688..2313969 (282 bp)
Type: Antitoxin
Protein ID: WP_003214273.1
Location: 2314263..2315429 (1167 bp)
Type: Others
Protein ID: WP_095407803.1
Location: 2315569..2316585 (1017 bp)
Type: Others
Protein ID: WP_095407802.1
Location: 2316746..2317111 (366 bp)
Type: Others
Protein ID: WP_205183266.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JVX94_RS119952308363..2308962-600WP_205183263.1SpoIIE family protein phosphatase-
JVX94_RS120002308962..2309750-789WP_024427378.1RNA polymerase sigma factor SigB-
JVX94_RS120052309716..2310204-489WP_048240335.1anti-sigma B factor RsbW-
JVX94_RS120102310201..2310530-330WP_017358393.1anti-sigma factor antagonist-
JVX94_RS120152310590..2311597-1008WP_095407804.1PP2C family protein-serine/threonine phosphatase-
JVX94_RS120202311608..2312009-402WP_024427376.1anti-sigma regulatory factor-
JVX94_RS120252312012..2312380-369WP_003214235.1RsbT antagonist protein RsbS-
JVX94_RS120302312385..2313215-831WP_024427375.1RsbT co-antagonist protein RsbRA-
JVX94_RS120352313333..2313683-351WP_024425388.1type II toxin-antitoxin system endoribonuclease NdoAToxin
JVX94_RS120402313688..2313969-282WP_003214273.1hypothetical proteinAntitoxin
JVX94_RS120452314263..2315429-1167WP_095407803.1alanine racemase-
JVX94_RS120502315569..2316585-1017WP_095407802.1outer membrane lipoprotein carrier protein LolA-
JVX94_RS120552316746..2317111-366WP_205183266.1holo-ACP synthase-
JVX94_RS120602317206..2317811+606WP_205183270.1rhomboid family intramembrane serine protease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T193900 WP_024425388.1 NZ_CP070345:c2313683-2313333 [Bacillus sp. PDNC022]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T193900 NZ_CP093271:c4711974-4711717 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT193900 WP_003214273.1 NZ_CP070345:c2313969-2313688 [Bacillus sp. PDNC022]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT193900 NZ_CP093271:c4711706-4711155 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGACCTGGTTGCCGATTTGCTCAACGATGAAAGTGCTCACCCGAGATTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0P7G713

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A081L854

References