Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /SpoIISA(toxin) |
Location | 1553738..1554716 | Replicon | chromosome |
Accession | NZ_CP070339 | ||
Organism | Bacillus cereus strain VKM B-370 |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | B7IX38 |
Locus tag | JTF64_RS07625 | Protein ID | WP_000624981.1 |
Coordinates | 1553979..1554716 (-) | Length | 246 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | B7IX39 |
Locus tag | JTF64_RS07620 | Protein ID | WP_000237817.1 |
Coordinates | 1553738..1553866 (-) | Length | 43 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTF64_RS07590 | 1549255..1549506 | + | 252 | WP_000821942.1 | response regulator transcription factor | - |
JTF64_RS07595 | 1549647..1550252 | - | 606 | WP_000527414.1 | hypothetical protein | - |
JTF64_RS07600 | 1550278..1551087 | - | 810 | WP_098832561.1 | C39 family peptidase | - |
JTF64_RS07605 | 1551400..1552869 | - | 1470 | WP_000287541.1 | beta-Ala-His dipeptidase | - |
JTF64_RS07610 | 1553081..1553470 | + | 390 | WP_000712655.1 | YxeA family protein | - |
JTF64_RS07615 | 1553489..1553665 | - | 177 | WP_098832560.1 | stage II sporulation protein SB | - |
JTF64_RS07620 | 1553738..1553866 | - | 129 | WP_000237817.1 | hypothetical protein | Antitoxin |
JTF64_RS07625 | 1553979..1554716 | - | 738 | WP_000624981.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
JTF64_RS07630 | 1554955..1555692 | - | 738 | WP_000594159.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
JTF64_RS07635 | 1555858..1556340 | - | 483 | WP_000191905.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
JTF64_RS07640 | 1556448..1556616 | + | 169 | Protein_1527 | hypothetical protein | - |
JTF64_RS07645 | 1556592..1557437 | + | 846 | Protein_1528 | alpha-keto acid decarboxylase family protein | - |
JTF64_RS07650 | 1557591..1558373 | - | 783 | WP_000381782.1 | class I SAM-dependent methyltransferase | - |
JTF64_RS07655 | 1558718..1559125 | - | 408 | WP_000072495.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28335.09 Da Isoelectric Point: 8.2998
>T193897 WP_000624981.1 NZ_CP070339:c1554716-1553979 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T193897 NZ_CP093271:899260-899670 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAACGGCGGATCCATGCCCGACAGGGGGAAATAAAGTTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGTCTGCGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAACGGCGGATCCATGCCCGACAGGGGGAAATAAAGTTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGTCTGCGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4981.37 Da Isoelectric Point: 3.9150
>AT193897 WP_000237817.1 NZ_CP070339:c1553866-1553738 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
Download Length: 129 bp
>AT193897 NZ_CP093271:899013-899279 [Klebsiella oxytoca]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6D1SWF1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B7IX39 |