Detailed information of TA system TA193896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3832174..3832859
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: JR349_RS17850
• Protein ID: WP_003417998.1
• Coordinates: 3832449..3832859 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JR349_RS17845
• Protein ID: WP_180895138.1
• Coordinates: 3832174..3832452 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS17825	3828163..3829764	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
JR349_RS17830	3829781..3830485	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
JR349_RS17835	3830603..3831169	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
JR349_RS17840	3831231..3832118	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
JR349_RS17845	3832174..3832452	+	279	WP_180895138.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JR349_RS17850	3832449..3832859	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
JR349_RS17855	3832892..3834628	-	1737	WP_003418002.1	cholesterol oxidase	-
JR349_RS17860	3834684..3835811	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
JR349_RS17865	3835831..3837420	-	1590	WP_003901630.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T193896 WP_003417998.1 NZ_CP070338:3832449-3832859 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T193896 NZ_CP093271:44582-44923 [Klebsiella oxytoca]
ATGTGGAATGTTGAAACAACGGAGGTTTTCGACAAGTGGTTTGAGGCGCAGACCGAAGCACTCAAAGAGGATATGCTCGC
CGCTATGGTGATCTTATCCGAGTATGGCCCCCAACTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCTTTTTCGA
ATATGAAAGAGTTACGCGTTCAGCATCAAGGTAGCCCGATCCGCGCTTTCTTTGTATTTGATCCTTCTCGTCGTGGCATC
CTGTTATGTGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10227.70 Da
• Isoelectric Point: 8.0222

>AT193896 WP_180895138.1 NZ_CP070338:3832174-3832452 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT193896 NZ_CP093271:44933-45232 [Klebsiella oxytoca]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAAGCGATGCG
TCAGGTTATCGCTTTAAGTATGTTAAGGGAGGAGCTGAATTTGTCTCAGGCCGAGCTGGCTAAGGCTATGGGTGTTAAAC
AGCCCACCATTGCTAAAATGGAGCAGGCCGATAACGACCCCCGCCTGTCAACGCTGAAGCGGTACGTTGCGGCGCTCGGG
GGTGAGTTAAGTATTGATGTTAAGCTGCCAGGCGGCAAGCGAATCGCATTCCATCTTTAA

Structures

Toxin

• AlphaFold DB: G0TIR9