Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3776044..3776573 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JR349_RS17590 Protein ID WP_003417760.1
Coordinates 3776316..3776573 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JR349_RS17585 Protein ID WP_003417757.1
Coordinates 3776044..3776319 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS17565 3772842..3774279 - 1438 Protein_3469 FAD-binding oxidoreductase -
JR349_RS17570 3774382..3774771 + 390 WP_003417745.1 DUF732 domain-containing protein -
JR349_RS17575 3774785..3775078 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JR349_RS17580 3775075..3775920 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JR349_RS17585 3776044..3776319 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JR349_RS17590 3776316..3776573 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JR349_RS17595 3776615..3777805 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JR349_RS17600 3777922..3778290 + 369 WP_003417765.1 FHA domain-containing protein -
JR349_RS17605 3778287..3778838 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JR349_RS17610 3778845..3779426 - 582 WP_003417769.1 ATP/GTP-binding protein -
JR349_RS17615 3779407..3779775 - 369 WP_003417772.1 DUF742 domain-containing protein -
JR349_RS17620 3779753..3780145 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T193894 WP_003417760.1 NZ_CP070338:3776316-3776573 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T193894 NZ_CP093260:c3130240-3129974 [Moellerella wisconsensis]
TTGGTCTGGACGATTAATTATTCTGAACGGGCGTTAAAATCTCTACGAAAAATGGATAAACAGAGTGCTCGCCGTATTGT
CGATTTTATGGGTTTACGCATTGCAGCTTTAGATGATCCCCGACAGTTAGGCAAATCACTCAAAGGTGAACTAGGTGAGT
TCTGGCGTTATAGAGTTGGTGACTATCGGATACTATGCGAGATAAGGGATGATGAACTTGTCATTTTGGCTGCTACAACA
GGACATCGTCGTGAGATATATGAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT193894 WP_003417757.1 NZ_CP070338:3776044-3776319 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT193894 NZ_CP093260:c3130448-3130224 [Moellerella wisconsensis]
ATGTTAGCTATTCGTTTATCTGATGACATTGAAACACGTCTGGAGTCACTTGCAAAACAGACAGGAAGAACCAAAACGTT
CTATGCGAGAGAAGCTATTCTCACCCACTTGGAAGACTTGGAAGACTACTATTTATCCGCTGAAACCATTGCAAAAATTC
GTAGCGGTGAAGAGTTGATTCATTCGTCTGAAGAGGTGAGAAAAACACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References