Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3705422..3706047 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JR349_RS17390 Protein ID WP_003403218.1
Coordinates 3705422..3705823 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JR349_RS17395 Protein ID WP_003403213.1
Coordinates 3705820..3706047 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS17365 3700512..3701459 - 948 WP_003403232.1 DUF732 domain-containing protein -
JR349_RS17370 3701563..3702627 - 1065 WP_003898532.1 hypothetical protein -
JR349_RS17375 3703022..3704113 - 1092 WP_003900977.1 galactokinase -
JR349_RS17380 3704110..3704601 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
JR349_RS17385 3704598..3705293 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
JR349_RS17390 3705422..3705823 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JR349_RS17395 3705820..3706047 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JR349_RS17400 3706242..3706484 - 243 WP_003403210.1 hypothetical protein -
JR349_RS17405 3706481..3707230 - 750 WP_003898528.1 hypothetical protein -
JR349_RS17410 3707314..3709881 + 2568 WP_003901879.1 SEC-C domain-containing protein -
JR349_RS17415 3709900..3710505 - 606 WP_003898526.1 hypothetical protein -
JR349_RS17420 3710647..3710868 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T193893 WP_003403218.1 NZ_CP070338:c3705823-3705422 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T193893 NZ_CP093260:2873820-2874044 [Moellerella wisconsensis]
ATGAATGAAAGACAGGAAAATATGACTAAAACAGACTATCTGATGCGTTTAAGAAAATGCACGACTATTGAAACATTAGA
GCGTGTTATTGAAAAAAATAAATATGAGCTATCTGATGATGAACTCGAACTGTTTTTTTCCGCTGCTGACCATCGTCTAG
CAGAACTAACAATGAATAAACTGTATGACAAAATTCCAGCATCTGTCTGGAAATATGTTCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT193893 WP_003403213.1 NZ_CP070338:c3706047-3705820 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT193893 NZ_CP093260:2873405-2873773 [Moellerella wisconsensis]
ATGGATGAATATTCACCCAGATATTACGATACTGCTGAATTAAAGTATTTATGTGATAGCCTTAACAATGATGCGATATT
ATCGCTACATAAGACTAAAACGCATTGGATTAATGATTTAAGTTCACAGCAAAGTACGAATTTGAATGAGTTAATAGAGC
ATGTGGCTGCATTTTTTTGGAAATTTAAGATAAAATACCCTAGTGAACGCTTATTCATCTCTCTAGTTGATGAATATCTT
GATGAAACTTATAATTTATTTGGTAGTCCATTAATCACATTAAATGAATTTTCAGATTGGCAAAAAATGAATACTCACTT
AATTGATGAATTAAATAACGATTTAAAGTGTTCAGTAGCCAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References