Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3698140..3698804 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag JR349_RS17340 Protein ID WP_003403246.1
Coordinates 3698140..3698547 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag JR349_RS17345 Protein ID WP_003403244.1
Coordinates 3698544..3698804 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS17330 3695097..3696824 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
JR349_RS17335 3696917..3698068 + 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
JR349_RS17340 3698140..3698547 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS17345 3698544..3698804 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR349_RS17350 3698936..3699676 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
JR349_RS17355 3699770..3700165 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
JR349_RS17360 3700165..3700419 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
JR349_RS17365 3700512..3701459 - 948 WP_003403232.1 DUF732 domain-containing protein -
JR349_RS17370 3701563..3702627 - 1065 WP_003898532.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T193891 WP_003403246.1 NZ_CP070338:c3698547-3698140 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T193891 NZ_CP093260:2676896-2677147 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCTGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT193891 WP_003403244.1 NZ_CP070338:c3698804-3698544 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT193891 NZ_CP093260:2677144-2677398 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References